Factor XIII-A in Diseases: Role Beyond Blood Coagulation
Abstract
:1. Introduction
2. FXIII-A in Diseases
2.1. FXIII-A in Wound Healing
2.2. FXIII-A in Chronic Inflammatory Bowel Diseases
2.3. FXIII-A in Atherosclerosis
2.4. FXIII-A in Rheumatoid Arthritis
2.5. FXIII-A in Chronic Inflammatory Lung Diseases
2.6. FXIII-A in Chronic Rhinosinusitis
2.7. FXIII-A in the Tumor Microenvironment
2.7.1. Solid Tumors
2.7.2. Dermatofibromas
2.7.3. Hematological Malignancies
Acute Leukemias
Hodgkin Lymphoma
2.8. FXIII-A and Obesity
3. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
AcP | Acide phosphatase |
AL | Acute leukemia |
ALP | Alkaline phosphatase |
ANAE | Alpha naphthyl acetate esterase |
ANLL | Acute non-lymphoid leukemia |
BALF | Bronchoalveolar lavage fluid |
BCP-ALL | B-cell progenitor acute lymphoblastic leukemia |
CCL2 C-C | Motif chemokine ligand 2 |
cFXIII-A | intracellular Factor XIII subunit A |
CD | Crohn’s disease |
CIA | Collagen-induced arthritis |
CIBD | Chronic inflammatory bowel diseases |
CRS | Chronic rhinosinusitis |
CRSsNP | Chronic rhinosinusitis without nasal polyp |
CRSwNP | Chronic rhinosinusitis with nasal polyp |
DF | Dermatofibroma |
DFSP | Dermatofibrosarcoma |
Egr-1 | Early growth response transcription factor 1 |
F13A | Factor XIII subunit A coding gene |
FXIII-A | Factor XIII subunit A |
FXIII-B | Factor XIII subunit B |
HLA-DR | Human leukocyte antigen - DR isotype |
ICAM | Intercellular adhesion molecule-1 |
IM | Inflammatory macrophage |
LIX | Lipopolysaccharide-induced CXC chemokine |
MAPK1 | Mitogen-activated protein kinase 1 |
NK | Natural killer cells |
pFXIII-A | Factor XIII subunit A in the plasma |
PI3K | Phosphatidylinositol 3 kinase |
PLA2G16 | Phospholipase 2A |
RA | Rheumatoid arthritis |
RANKL | Receptor activator of NFκB ligand |
SNP | Single nucleotide polymorphism |
TAM | Tumor associated macrophage |
WBC | White blood cell |
AcP | Acide phosphatase |
AL | Acute leukemia |
ALP | Alkaline phosphatase |
ANAE | Alpha naphthyl acetate esterase |
ANLL | Acute non-lymphoid leukemia |
BALF | Bronchoalveolar lavage fluid |
BCP-ALL | B-cell progenitor acute lymphoblastic leukemia |
CCL2 C-C | Motif chemokine ligand 2 |
cFXIII-A | intracellular Factor XIII subunit A |
CD | Crohn’s disease |
CIA | Collagen-induced arthritis |
CIBD | Chronic inflammatory bowel diseases |
CRS | Chronic rhinosinusitis |
CRSsNP | Chronic rhinosinusitis without nasal polyp |
CRSwNP | Chronic rhinosinusitis with nasal polyp |
DF | Dermatofibroma |
DFSP | Dermatofibrosarcoma |
Egr-1 | Early growth response transcription factor 1 |
F13A | Factor XIII subunit A coding gene |
FXIII-A | Factor XIII subunit A |
FXIII-B | Factor XIII subunit B |
HLA-DR | Human leukocyte antigen - DR isotype |
ICAM | Intercellular adhesion molecule-1 |
IM | Inflammatory macrophage |
LIX | Lipopolysaccharide-induced CXC chemokine |
MAPK1 | Mitogen-activated protein kinase 1 |
NK | Natural killer cells |
pFXIII-A | Factor XIII subunit A in the plasma |
PI3K | Phosphatidylinositol 3 kinase |
PLA2G16 | Phospholipase 2A |
RA | Rheumatoid arthritis |
RANKL | Receptor activator of NFκB ligand |
SNP | Single nucleotide polymorphism |
TAM | Tumor associated macrophage |
WBC | White blood cell |
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Dull, K.; Fazekas, F.; Törőcsik, D. Factor XIII-A in Diseases: Role Beyond Blood Coagulation. Int. J. Mol. Sci. 2021, 22, 1459. https://doi.org/10.3390/ijms22031459
Dull K, Fazekas F, Törőcsik D. Factor XIII-A in Diseases: Role Beyond Blood Coagulation. International Journal of Molecular Sciences. 2021; 22(3):1459. https://doi.org/10.3390/ijms22031459
Chicago/Turabian StyleDull, Katalin, Fruzsina Fazekas, and Dániel Törőcsik. 2021. "Factor XIII-A in Diseases: Role Beyond Blood Coagulation" International Journal of Molecular Sciences 22, no. 3: 1459. https://doi.org/10.3390/ijms22031459