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Article

Synthesis and Self-Assembly Properties of Bola-Amphiphilic Glycosylated Lipopeptide-Type Supramolecular Hydrogels Showing Colour Changes Along with Gel–Sol Transition

by
Naoki Tsutsumi
1,
Akitaka Ito
2,3,
Azumi Ishigamori
4,
Masato Ikeda
5,6,
Masayuki Izumi
1,4,7,8 and
Rika Ochi
1,4,7,8,*
1
Graduate School of Integrated Arts and Sciences, Kochi University, 2-5-1, Akebono-cho, Kochi 780-8520, Japan
2
School of Environmental Science and Engineering, Kochi University of Technology, Kami, Kochi 782-8502, Japan
3
Research Center for Molecular Design, Kochi University of Technology, Kami, Kochi 782-8502, Japan
4
Faculty of Science, Kochi University, 2-5-1, Akebono-cho, Kochi 780-8520, Japan
5
Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
6
United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
7
Interdisciplinary Science Unit, Multidisciplinary Sciences Cluster, Research and Education Faculty, Kochi University, 2-5-1, Akebono-cho, Kochi 780-8520, Japan
8
Faculty of Science and Technology, Kochi University, 2-5-1, Akebono-cho, Kochi 780-8520, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(4), 1860; https://doi.org/10.3390/ijms22041860
Submission received: 19 January 2021 / Revised: 1 February 2021 / Accepted: 9 February 2021 / Published: 13 February 2021
(This article belongs to the Special Issue Self-Assembly Mechanism and Connection of Peptides and Proteins)
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Abstract

Supramolecular hydrogels formed by self-assembly of low-molecular-weight amphiphiles (hydrogelators) have attracted significant attention, as smart and soft materials. However, most of the observed stimuli-responsive behaviour of these supramolecular hydrogels are limited to gel–sol transitions. In this study, we present bola-amphiphilic glycosylated lipopeptide-type supramolecular hydrogelators that exhibit reversible thermochromism along with a gel–sol transition. The bola-amphiphiles have mono-, di-, tri- or tetra-phenylalanine (F) as a short peptide moiety. We investigate and discuss the effects of the number of F residues on the gelation ability and the morphology of the self-assembled nanostructures.
Keywords: self-assembly; peptide; supramolecular hydrogel; chromism self-assembly; peptide; supramolecular hydrogel; chromism

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MDPI and ACS Style

Tsutsumi, N.; Ito, A.; Ishigamori, A.; Ikeda, M.; Izumi, M.; Ochi, R. Synthesis and Self-Assembly Properties of Bola-Amphiphilic Glycosylated Lipopeptide-Type Supramolecular Hydrogels Showing Colour Changes Along with Gel–Sol Transition. Int. J. Mol. Sci. 2021, 22, 1860. https://doi.org/10.3390/ijms22041860

AMA Style

Tsutsumi N, Ito A, Ishigamori A, Ikeda M, Izumi M, Ochi R. Synthesis and Self-Assembly Properties of Bola-Amphiphilic Glycosylated Lipopeptide-Type Supramolecular Hydrogels Showing Colour Changes Along with Gel–Sol Transition. International Journal of Molecular Sciences. 2021; 22(4):1860. https://doi.org/10.3390/ijms22041860

Chicago/Turabian Style

Tsutsumi, Naoki, Akitaka Ito, Azumi Ishigamori, Masato Ikeda, Masayuki Izumi, and Rika Ochi. 2021. "Synthesis and Self-Assembly Properties of Bola-Amphiphilic Glycosylated Lipopeptide-Type Supramolecular Hydrogels Showing Colour Changes Along with Gel–Sol Transition" International Journal of Molecular Sciences 22, no. 4: 1860. https://doi.org/10.3390/ijms22041860

APA Style

Tsutsumi, N., Ito, A., Ishigamori, A., Ikeda, M., Izumi, M., & Ochi, R. (2021). Synthesis and Self-Assembly Properties of Bola-Amphiphilic Glycosylated Lipopeptide-Type Supramolecular Hydrogels Showing Colour Changes Along with Gel–Sol Transition. International Journal of Molecular Sciences, 22(4), 1860. https://doi.org/10.3390/ijms22041860

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