Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research

Park, Yujin; Huh, Kang Moo; Kang, Sun-Woong

doi:10.3390/ijms22052491

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Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research

by

Yujin Park

^1,2,

Kang Moo Huh

^1,*,† and

Sun-Woong Kang

^2,3,*,†

¹

Department of Polymer Science and Engineering & Chemical Engineering and Applied Chemistry, Chungnam National University, Daejeon 34134, Korea

²

Predictive Model Research Center, Korea Institute of Toxicology, Daejeon 34114, Korea

³

Human and Environmental Toxicology Program, University of Science and Technology, Daejeon 34114, Korea

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Int. J. Mol. Sci. 2021, 22(5), 2491; https://doi.org/10.3390/ijms22052491

Submission received: 20 December 2020 / Revised: 25 February 2021 / Accepted: 25 February 2021 / Published: 2 March 2021

(This article belongs to the Collection Feature Papers in Molecular Pharmacology)

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Abstract

The process of evaluating the efficacy and toxicity of drugs is important in the production of new drugs to treat diseases. Testing in humans is the most accurate method, but there are technical and ethical limitations. To overcome these limitations, various models have been developed in which responses to various external stimuli can be observed to help guide future trials. In particular, three-dimensional (3D) cell culture has a great advantage in simulating the physical and biological functions of tissues in the human body. This article reviews the biomaterials currently used to improve cellular functions in 3D culture and the contributions of 3D culture to cancer research, stem cell culture and drug and toxicity screening.

Keywords: 3D cell culture; biomaterials; drug screening; alternative model

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MDPI and ACS Style

Park, Y.; Huh, K.M.; Kang, S.-W. Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research. Int. J. Mol. Sci. 2021, 22, 2491. https://doi.org/10.3390/ijms22052491

AMA Style

Park Y, Huh KM, Kang S-W. Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research. International Journal of Molecular Sciences. 2021; 22(5):2491. https://doi.org/10.3390/ijms22052491

Chicago/Turabian Style

Park, Yujin, Kang Moo Huh, and Sun-Woong Kang. 2021. "Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research" International Journal of Molecular Sciences 22, no. 5: 2491. https://doi.org/10.3390/ijms22052491

APA Style

Park, Y., Huh, K. M., & Kang, S.-W. (2021). Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research. International Journal of Molecular Sciences, 22(5), 2491. https://doi.org/10.3390/ijms22052491

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research

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