Electrophysiological Properties of Endogenous Single Ca2+ Activated Cl− Channels Induced by Local Ca2+ Entry in HEK293
Abstract
:1. Introduction
2. Results
2.1. IP3-Induced Calcium Entry through TRPC1 Activates Outwardly Rectifying CaCCs in HEK293 Cells
2.2. Direct Activation of Endogenous CaCCs in HEK293 by High [Ca2+]i
2.3. Functional Coupling and Close Arrangement of Endogenous TRPC1 Channels and CaCCs
3. Discussion
4. Materials and Methods
4.1. Cells
4.2. Electrophysiological Analysis
4.3. Statistical Analysis
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Kolesnikov, D.; Perevoznikova, A.; Gusev, K.; Glushankova, L.; Kaznacheyeva, E.; Shalygin, A. Electrophysiological Properties of Endogenous Single Ca2+ Activated Cl− Channels Induced by Local Ca2+ Entry in HEK293. Int. J. Mol. Sci. 2021, 22, 4767. https://doi.org/10.3390/ijms22094767
Kolesnikov D, Perevoznikova A, Gusev K, Glushankova L, Kaznacheyeva E, Shalygin A. Electrophysiological Properties of Endogenous Single Ca2+ Activated Cl− Channels Induced by Local Ca2+ Entry in HEK293. International Journal of Molecular Sciences. 2021; 22(9):4767. https://doi.org/10.3390/ijms22094767
Chicago/Turabian StyleKolesnikov, Dmitrii, Anastasiia Perevoznikova, Konstantin Gusev, Lyubov Glushankova, Elena Kaznacheyeva, and Alexey Shalygin. 2021. "Electrophysiological Properties of Endogenous Single Ca2+ Activated Cl− Channels Induced by Local Ca2+ Entry in HEK293" International Journal of Molecular Sciences 22, no. 9: 4767. https://doi.org/10.3390/ijms22094767