Role of Ion-Channels in Signal Transduction and Gene Regulation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 18080
Special Issue Editors
Interests: calcium signaling; STIM; orai proteins
Special Issues, Collections and Topics in MDPI journals
Interests: calcium signaling; CRAC; STIM; Orai; autophagy; transcription factor activation; MITF; TFEB
Special Issue Information
Dear Colleagues,
Signal transduction subsequent to ion flux across channels that are located in the plasma membrane and organelle membranes can regulate the expression of several genes. Extensive research is still required in order to understand how these signaling pathways are controlled in time and space, and which specific signaling proteins are involved. Therefore, we are organizing this Special Issue in order to resolve ion-dependent signaling pathways. The activity of several ion channels regulates various intracellular ion concentrations and activates either locally (microdomains) or globally specific signaling cascades. The most prominent second messenger ion is represented by calcium in excitable and non-excitable cells. This ion can lead to transcription factor activation followed by associated gene expression. However, other ions like Mg2+ and K+ also contribute to the regulation of transcription factor activation.
The aim of this Special Issue of the International Journal of Molecular Sciences is to further expand our current knowledge on the relationship between ion flux, signal transduction, and gene expression. We welcome reviews and original research articles that explore, but are not limited to, the structure and function of calcium signaling complexes and ion-dependent stimulation of gene regulation.
Dr. Rainer Schindl
Dr. Romana Schober
Guest Editors
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Keywords
- ion channels
- ion channel signaling complexes
- transcription factor
- calcium
- potassium
- autophagy
- transcriptional regulation
- gene expression
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