The Role of DNA Repair in Genomic Instability of Multiple Myeloma

Round 1

Reviewer 1 Report

In this review, Ismail et al. attempt to provide an overview of DNA repair pathways in genomic instability of multiple myeloma (MM).  The treatment outcome of MM has been significantly improved by the introduction of novel therapeutic agents.  However, MM remains incurable, and patients often go through serial cycles of response, remission, and relapse over the disease progression.  Therefore, resistance to chemotherapy remains a persistent challenge of the clinic.  Previous studies revealed the roles of the increasing genomic complexity of the tumors and the additional acquisition of a myriad of mutations and epigenetic alterations in relapse and drug resistance.  Based on these findings, this review provides an overview of DNA repair pathways with a special focus on their involvement in MM and discusses the role of DNA repair in genomic instability and drug resistance. 

This reviewer thinks that the manuscript is presented in a clear and well-structured manner.  This review would be beneficial for readers to understand the role of DNA repair in genomic instability and drug resistance in MM.  However, there are several minor points that need to be corrected.

Minor points

References #50, 92, 94, 102, 112, 117, 122, 125, and 126; The authors should show the volume number, pages, and publication year. 

Author Response

We thank the reviewer for this comment. All the references mentioned above have been corrected and marked in red on the revised manuscript.

Reviewer 2 Report

The manuscript entitled “The Role of DNA repair in Genomic Instability of Multiple Myeloma” by Dr. Ali et al was well written and reviewed DNA repair pathways in MM and discussed their role in MM progression and drug resistance. It explained in detail how unrepaired DNA damage and DNA repair response in MM exacerbated genomic instability and chromosomal abnormalities. The structure of the manuscript is well organized, and the overall quality is excellent. I have nothing to add in.

Author Response

We thank the reviewer for their time and effort. We are happy that the reviewer likes the work. Thank you.