Rationally Designed Antimicrobial Peptides Are Potential Tools to Combat Devastating Bacteria and Fungi
Funding
Conflicts of Interest
References
- Murray, C.J.; Ikuta, K.S.; Sharara, F.; Swetschinski, L.; Aguilar, G.R.; Gray, A.; Han, C.; Bisignano, C.; Rao, P.; Wool, E.; et al. Global burden of bacterial antimicrobial resistance in 2019: A systematic analysis. Lancet 2022, 399, 629–655. [Google Scholar] [CrossRef]
- Mansura, S.M.; Ekta, E.K.; Shital, N.K.; Madhumita, S.T.; Karishma, R.P. Emerging strategies to combat ESKAPE pathogens in the era of antimicrobial resistance: A Review. Front. Microbiol. 2019, 10, 539. [Google Scholar] [CrossRef]
- Magana, M.; Pushpanathan, M.; Santos, A.L.; Leanse, L.; Ioannidis, M.F.A.; Giulianotti, M.A.; Bradfute, Y.A.S.; Ferguson, A.L.; Cherkasov, A.; Seleem, M.N.; et al. The value of antimicrobial peptides in the age of resistance. Lancet Infect. Dis. 2020, 20, e216–e230. [Google Scholar] [CrossRef]
- Kainz, K.; Bauer, M.A.; Madeo, F.; Carmona-Gutierrez, D. Fungal infections in humans: The silent crisis. Microb. Cell. 2020, 1, 143–145. [Google Scholar] [CrossRef] [PubMed]
- León-Buitimea, A.; Garza-Cárdenas, C.R.; Garza-Cervantes, J.A.; Lerma-Escalera, J.A.; Morones-Ramírez, J.R. The demand for new antibiotics: Antimicrobial peptides, nanoparticles, and combinatorial therapies as future strategies in antibacterial agent design. Front. Microbiol. 2020, 11, 1669. [Google Scholar] [CrossRef]
- Fuentefria, A.M.; Pippi, B.; Dalla Lana, D.F.; Donato, K.K.; de Andrade, S.F. Antifungals discovery: An insight into new strategies to combat antifungal resistance. Lett. Appl. Microbiol. 2018, 66, 2–13. [Google Scholar] [CrossRef] [Green Version]
- McEwen, S.A.; Collignon, P.J. Antimicrobial resistance: A one health perspective. Microbiol. Spectr. 2018, 6, 2. [Google Scholar] [CrossRef] [Green Version]
- Mann, A.; Nehra, K.; Rana, J.S.; Dahiya, T. Antibiotic resistance in agriculture: Perspectives on upcoming strategies to overcome upsurge in resistance. Curr. Res. Microb. Sci. 2021, 2, 100030. [Google Scholar] [CrossRef]
- Jenssen, H.; Hamill, P.; Hancock, R.E.W. Peptide antimicrobial agents. Clin. Microbiol. Rev. 2006, 19, 491–511. [Google Scholar] [CrossRef] [Green Version]
- Chellat, M.F.; Raguž, L.; Riedl, R. Targeting antibiotic resistance. Angew. Chem. Int. Ed. 2016, 55, 2–30. [Google Scholar] [CrossRef]
- Mahlapuu, M.; Björn, C.; Ekblom, J. Antimicrobial peptides as therapeutic agents: Opportunities and challenges. Crit. Rev. Biotechnol. 2020, 40, 978–992. [Google Scholar] [CrossRef]
- Zasloff, M. Antimicrobial peptides of multicellular organisms. Nature 2002, 415, 389–395. [Google Scholar] [CrossRef]
- Jenei, S.; Tiricz, H.; Szolomájer, J.; Tímár, E.; Klement, E.; Al Bouni, M.A.; Lima, R.M.; Kata, D.; Harmati, M.; Buzás, K.; et al. Potent chimeric antimicrobial derivatives of the Medicago truncatula NCR247 symbiotic peptide. Front. Microbiol. 2020, 11, 270. [Google Scholar] [CrossRef]
- Szerencsés, B.; Gácser, A.; Endre, G.; Domonkos, I.; Tiricz, H.; Vágvölgyi, C.; Szolomájer, J.; Howan, D.H.O.; Tóth, G.K.; Pfeiffer, I.; et al. Symbiotic NCR peptide fragments affect the viability, morphology and biofilm formation of Candida species. Int. J. Mol. Sci. 2021, 22, 3666. [Google Scholar] [CrossRef]
- Sonderegger, C.; Váradi, G.; Galgóczy, L.; Kocsubé, S.; Posch, W.; Borics, A.; Dubrac, S.; Tóth, G.K.; Wilflingseder, D.; Marx, F. The evolutionary conserved γ-core motif influences the anti-Candida activity of the Penicillium chrysogenum antifungal protein PAF. Front. Microbiol. 2018, 9, 1655. [Google Scholar] [CrossRef]
- Tóth, L.; Boros, E.; Poór, P.; Ördög, A.; Kele, Z.; Váradi, G.; Holzknecht, J.; Bratschun-Khan, D.; Nagy, I.; Tóth, G.K.; et al. The potential use of the Penicillium chrysogenum antifungal protein PAF, the designed variant PAFopt and its γ-core peptide Pγopt in plant protection. Microb. Biotechnol. 2020, 13, 1403–1414. [Google Scholar] [CrossRef] [Green Version]
- Tóth, L.; Váradi, G.; Boros, E.; Borics, A.; Ficze, H.; Nagy, I.; Tóth, G.K.; Rákhely, G.; Marx, F.; Galgóczy, L. Biofungicidal potential of Neosartorya (Aspergillus) fischeri antifungal protein NFAP and novel synthetic γ-core peptides. Front. Microbiol. 2020, 11, 820. [Google Scholar] [CrossRef]
- Tóth, L.; Poór, P.; Ördög, A.; Váradi, G.; Farkas, A.; Papp, C.; Bende, G.; Tóth, G.K.; Rákhely, G.; Marx, F.; et al. The combination of Neosartorya (Aspergillus) fischeri antifungal proteins with rationally designed γ-core peptide derivatives is effective for plant and crop protection. BioControl 2022, 67, 249–262. [Google Scholar] [CrossRef]
- Roy, P.; Achom, M.; Wilkinson, H.; Lagunas, B.; Gifford, M.L. Symbiotic outcome modified by the diversification from 7 to over 700 nodule-specific cysteine-rich peptides. Genes 2020, 11, 348. [Google Scholar] [CrossRef] [Green Version]
- Lima, R.M.; Kylarová, S.; Mergaert, P.; Kondorosi, E. Unexplored arsenals of legume peptides with potential for their applications in medicine and agriculture. Front. Microbiol. 2020, 11, 1307. [Google Scholar] [CrossRef]
- Isozumi, N.; Masubuchi, Y.; Imamura, T.; Mori, M.; Koga, H.; Ohki, S. Structure and antimicrobial activity of NCR169, a nodule-specifc cysteine-rich peptide of Medicago truncatula. Sci. Rep. 2021, 11, 9923. [Google Scholar] [CrossRef] [PubMed]
- Farkas, A.; Maróti, G.; Kereszt, A.; Kondorosi, E. Comparative analysis of the bacterial membrane disruption effect of two natural plant antimicrobial peptides. Front. Microbiol. 2017, 8, 51. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Armas, F.; Di Stasi, A.; Mardirossian, M.; Romani, A.A.; Benincasa, M.; Scocchi, M. Effects of lipidation on a proline-rich antibacterial peptide. Int. J. Mol. Sci. 2021, 22, 7959. [Google Scholar] [CrossRef] [PubMed]
- Janicka-Kłos, A.; Czapor-Irzabek, H.; Janek, T. The potential antimicrobial action of human mucin 7 15-mer peptide and its metal complexes. Int. J. Mol. Sci. 2022, 23, 418. [Google Scholar] [CrossRef]
- Małuch, I.; Stachurski, O.; Kosikowska-Adamus, P.; Makowska, M.; Bauer, M.; Wyrzykowski, D.; Hać, A.; Kamysz, W.; Deptuła, M.; Pikuła, M.; et al. Double-headed cationic lipopeptides: An emerging class of antimicrobials. Int. J. Mol. Sci. 2020, 21, 8944. [Google Scholar] [CrossRef]
- Nikapitiya, C.; Dananjaya, S.H.S.; Chandrarathna, H.P.S.U.; De Zoysa, M.; Whang, I. Octominin: A novel synthetic anticandidal peptide derived from defense protein of Octopus minor. Mar. Drugs 2020, 18, 56. [Google Scholar] [CrossRef] [Green Version]
- Thulshan Jayathilaka, E.H.T.; Rajapaksha, D.C.; Nikapitiya, C.; De Zoysa, M.; Whang, I. Antimicrobial and anti-biofilm peptide octominin for controlling multidrug-resistant Acinetobacter baumannii. Int. J. Mol. Sci. 2021, 22, 5353. [Google Scholar] [CrossRef]
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. |
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Váradi, G.; Galgóczy, L.; Tóth, G.K. Rationally Designed Antimicrobial Peptides Are Potential Tools to Combat Devastating Bacteria and Fungi. Int. J. Mol. Sci. 2022, 23, 6244. https://doi.org/10.3390/ijms23116244
Váradi G, Galgóczy L, Tóth GK. Rationally Designed Antimicrobial Peptides Are Potential Tools to Combat Devastating Bacteria and Fungi. International Journal of Molecular Sciences. 2022; 23(11):6244. https://doi.org/10.3390/ijms23116244
Chicago/Turabian StyleVáradi, Györgyi, László Galgóczy, and Gábor K. Tóth. 2022. "Rationally Designed Antimicrobial Peptides Are Potential Tools to Combat Devastating Bacteria and Fungi" International Journal of Molecular Sciences 23, no. 11: 6244. https://doi.org/10.3390/ijms23116244