Exercise Training Enhances BDNF/TrkB Signaling Pathway and Inhibits Apoptosis in Diabetic Cerebral Cortex
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Diabetes Induction
2.3. Experimental Groups and Procedures
2.4. Hematoxylin and Eosin (H&E) Stain
2.5. TUNEL Assay
2.6. Western Blot Analysis
2.7. Statistical Analysis
3. Results
3.1. Neural Histopathology and TUNEL(+) Apoptotic Cells
3.2. Neural Extrinsic (Fas/FasL-Mediated) Apoptotic Pathway
3.3. Neural Intrinsic (Mitochondria-Initiated) Apoptotic Pathway
3.4. Neural BDNF/TrkB and PI3K/AKT Survival Pathway
3.5. Neural Ras/MEK/MAPK/ERK Signaling Pathway
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Cheng, S.-M.; Lee, S.-D. Exercise Training Enhances BDNF/TrkB Signaling Pathway and Inhibits Apoptosis in Diabetic Cerebral Cortex. Int. J. Mol. Sci. 2022, 23, 6740. https://doi.org/10.3390/ijms23126740
Cheng S-M, Lee S-D. Exercise Training Enhances BDNF/TrkB Signaling Pathway and Inhibits Apoptosis in Diabetic Cerebral Cortex. International Journal of Molecular Sciences. 2022; 23(12):6740. https://doi.org/10.3390/ijms23126740
Chicago/Turabian StyleCheng, Shiu-Min, and Shin-Da Lee. 2022. "Exercise Training Enhances BDNF/TrkB Signaling Pathway and Inhibits Apoptosis in Diabetic Cerebral Cortex" International Journal of Molecular Sciences 23, no. 12: 6740. https://doi.org/10.3390/ijms23126740