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Volume 23
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Review

Hypercholesterolemia in Cancer and in Anorexia Nervosa: A Hypothesis for a Crosstalk

by
Giulia Gizzi
1,
Samuela Cataldi
2,
Claudia Mazzeschi
1,
Elisa Delvecchio
1,
Maria Rachele Ceccarini
2,
Michela Codini
2 and
Elisabetta Albi
2,*
1
Department of Philosophy, Social Sciences and Education, University of Perugia, 06126 Perugia, Italy
2
Department of Pharmaceutical Sciences, University of Perugia, 06126 Perugia, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(13), 7466; https://doi.org/10.3390/ijms23137466
Submission received: 31 May 2022 / Revised: 30 June 2022 / Accepted: 4 July 2022 / Published: 5 July 2022
(This article belongs to the Special Issue Lipid as a Cancer Therapeutic Target 2.0)
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Abstract

The relationship between cholesterol and cancer has been widely demonstrated. Clinical studies have shown changes in blood cholesterol levels in cancer patients. In parallel, basic research studies have shown that cholesterol is involved in the mechanisms of onset and progression of the disease. On the other hand, anorexic patients have high cholesterol levels and a high susceptibility to cancer. In this review, we first present a brief background on the relations among nutrition, eating disorders and cancer. Using several notable examples, we then illustrate the changes in cholesterol in cancer and in anorexia nervosa, providing evidence for their important relationship. Finally, we show a new possible link between cholesterol disorder in cancer and in anorexia nervosa.
Keywords: cancer; hypercholesterolemia; anorexia nervosa; lipids; sphingomyelinase; keratinocytes cancer; hypercholesterolemia; anorexia nervosa; lipids; sphingomyelinase; keratinocytes

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MDPI and ACS Style

Gizzi, G.; Cataldi, S.; Mazzeschi, C.; Delvecchio, E.; Ceccarini, M.R.; Codini, M.; Albi, E. Hypercholesterolemia in Cancer and in Anorexia Nervosa: A Hypothesis for a Crosstalk. Int. J. Mol. Sci. 2022, 23, 7466. https://doi.org/10.3390/ijms23137466

AMA Style

Gizzi G, Cataldi S, Mazzeschi C, Delvecchio E, Ceccarini MR, Codini M, Albi E. Hypercholesterolemia in Cancer and in Anorexia Nervosa: A Hypothesis for a Crosstalk. International Journal of Molecular Sciences. 2022; 23(13):7466. https://doi.org/10.3390/ijms23137466

Chicago/Turabian Style

Gizzi, Giulia, Samuela Cataldi, Claudia Mazzeschi, Elisa Delvecchio, Maria Rachele Ceccarini, Michela Codini, and Elisabetta Albi. 2022. "Hypercholesterolemia in Cancer and in Anorexia Nervosa: A Hypothesis for a Crosstalk" International Journal of Molecular Sciences 23, no. 13: 7466. https://doi.org/10.3390/ijms23137466

APA Style

Gizzi, G., Cataldi, S., Mazzeschi, C., Delvecchio, E., Ceccarini, M. R., Codini, M., & Albi, E. (2022). Hypercholesterolemia in Cancer and in Anorexia Nervosa: A Hypothesis for a Crosstalk. International Journal of Molecular Sciences, 23(13), 7466. https://doi.org/10.3390/ijms23137466

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