Next Article in Journal
Emerging Anti-Inflammatory Pharmacotherapy and Cell-Based Therapy for Lymphedema
Next Article in Special Issue
Specific Isolation of Clostridium botulinum Group I Cells by Phage Lysin Cell Wall Binding Domain with the Aid of S-Layer Disruption
Previous Article in Journal
Impact of the Exposome on the Epigenome in Inflammatory Bowel Disease Patients and Animal Models
Previous Article in Special Issue
Host Range, Morphology and Sequence Analysis of Ten Temperate Phages Isolated from Pathogenic Yersinia enterocolitica Strains
 
 
Article
Peer-Review Record

Cloning and Characterization of a Thermostable Endolysin of Bacteriophage TP-84 as a Potential Disinfectant and Biofilm-Removing Biological Agent

Int. J. Mol. Sci. 2022, 23(14), 7612; https://doi.org/10.3390/ijms23147612
by Joanna Żebrowska 1,*, Olga Żołnierkiewicz 1, Małgorzata Ponikowska 1, Michał Puchalski 2, Natalia Krawczun 1, Joanna Makowska 3 and Piotr Skowron 1
Reviewer 1:
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2022, 23(14), 7612; https://doi.org/10.3390/ijms23147612
Submission received: 5 May 2022 / Revised: 27 June 2022 / Accepted: 5 July 2022 / Published: 9 July 2022
(This article belongs to the Special Issue Bacteriophage—Molecular Studies 4.0)

Round 1

Reviewer 1 Report

Although the study is valuable, it has some shortcomings. Various situations should be considered that will increase the research value. The introduction and method section should be modified with a clear understanding for readers and should be rearranged to be more understandable.

Typos should be corrected. The article should be accepted after minor revision.

Comments for author File: Comments.docx

Author Response

Please see the attachment

Author Response File: Author Response.docx

Reviewer 2 Report

The authors described and characterized a thermostable lysin from phage. The work is quite straightforward and descriptive on the biochemical characterization of the lysin, however, relevance on the biological background and the application potent of such lysin molecule can be further strengthened. The advantage of this lysin over other known lysins was also largely ignored.

How active is the lysin against biofilm? For the host range, more relevant strains should be tested.

Author Response

Please see the attachment

Author Response File: Author Response.docx

Back to TopTop