The Impairment of Cell Metabolism by Cardiovascular Toxicity of Doxorubicin Is Reversed by Bergamot Polyphenolic Fraction Treatment in Endothelial Cells
Abstract
:1. Introduction
2. Results
2.1. Toxic Action of DOX on the Viability of pAECs and the Effects of BPF
2.2. Protection from Damage of DOX by BPF on Mitochondrial Metabolism of the pAECs
3. Discussion
4. Materials and Methods
4.1. Chemicals and Reagents
4.2. Preparation of the Bergamot Polyphenolic Fraction (BPF)
4.3. Cell Cultures
4.4. Cell Viability
4.5. Cellular Metabolism
4.6. Statistical Analyses
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Algieri, C.; Bernardini, C.; Oppedisano, F.; La Mantia, D.; Trombetti, F.; Palma, E.; Forni, M.; Mollace, V.; Romeo, G.; Troisio, I.; et al. The Impairment of Cell Metabolism by Cardiovascular Toxicity of Doxorubicin Is Reversed by Bergamot Polyphenolic Fraction Treatment in Endothelial Cells. Int. J. Mol. Sci. 2022, 23, 8977. https://doi.org/10.3390/ijms23168977
Algieri C, Bernardini C, Oppedisano F, La Mantia D, Trombetti F, Palma E, Forni M, Mollace V, Romeo G, Troisio I, et al. The Impairment of Cell Metabolism by Cardiovascular Toxicity of Doxorubicin Is Reversed by Bergamot Polyphenolic Fraction Treatment in Endothelial Cells. International Journal of Molecular Sciences. 2022; 23(16):8977. https://doi.org/10.3390/ijms23168977
Chicago/Turabian StyleAlgieri, Cristina, Chiara Bernardini, Francesca Oppedisano, Debora La Mantia, Fabiana Trombetti, Ernesto Palma, Monica Forni, Vincenzo Mollace, Giovanni Romeo, Ilaria Troisio, and et al. 2022. "The Impairment of Cell Metabolism by Cardiovascular Toxicity of Doxorubicin Is Reversed by Bergamot Polyphenolic Fraction Treatment in Endothelial Cells" International Journal of Molecular Sciences 23, no. 16: 8977. https://doi.org/10.3390/ijms23168977