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Review

Use of the Probiotic Bifidobacterium animalis subsp. lactis HN019 in Oral Diseases

by
Lisa Danielly Curcino Araujo
1,
Flávia Aparecida Chaves Furlaneto
2,
Léa Assed Bezerra da Silva
1 and
Yvonne L. Kapila
3,*
1
Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil
2
Department of Oral & Maxillofacial Surgery, and Periodontology, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil
3
Department of Dentistry, Sections of Biosystems and Function and Periodontics, School of Dentistry, University of California Los Angeles, Los Angeles, CA 90095, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(16), 9334; https://doi.org/10.3390/ijms23169334
Submission received: 2 August 2022 / Revised: 16 August 2022 / Accepted: 16 August 2022 / Published: 19 August 2022

Abstract

The oral cavity is one of the environments on the human body with the highest concentrations of microorganisms that coexist harmoniously and maintain homeostasis related to oral health. Several local factors can shift the microbiome to a pathogenic state of dysbiosis. Existing treatments for infections caused by changes in the oral cavity aim to control biofilm dysbiosis and restore microbial balance. Studies have used probiotics as treatments for oral diseases, due to their ability to reduce the pathogenicity of the microbiota and immunoinflammatory changes. This review investigates the role of the probiotic Bifidobacterium animalis subsp. lactis (B. lactis) HN019 in oral health, and its mechanism of action in pre-clinical and clinical studies. This probiotic strain is a lactic acid bacterium that is safe for human consumption. It mediates bacterial co-aggregation with pathogens and modulates the immune response. Studies using B. lactis HN019 in periodontitis and peri-implant mucositis have shown it to be a potential adjuvant treatment with beneficial microbiological and immunological effects. Studies evaluating its oral effects and mechanism of action show that this probiotic strain has the potential to be used in several dental applications because of its benefit to the host.
Keywords: probiotic; endodontics; oral health; dysbiosis; periodontitis probiotic; endodontics; oral health; dysbiosis; periodontitis

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MDPI and ACS Style

Araujo, L.D.C.; Furlaneto, F.A.C.; da Silva, L.A.B.; Kapila, Y.L. Use of the Probiotic Bifidobacterium animalis subsp. lactis HN019 in Oral Diseases. Int. J. Mol. Sci. 2022, 23, 9334. https://doi.org/10.3390/ijms23169334

AMA Style

Araujo LDC, Furlaneto FAC, da Silva LAB, Kapila YL. Use of the Probiotic Bifidobacterium animalis subsp. lactis HN019 in Oral Diseases. International Journal of Molecular Sciences. 2022; 23(16):9334. https://doi.org/10.3390/ijms23169334

Chicago/Turabian Style

Araujo, Lisa Danielly Curcino, Flávia Aparecida Chaves Furlaneto, Léa Assed Bezerra da Silva, and Yvonne L. Kapila. 2022. "Use of the Probiotic Bifidobacterium animalis subsp. lactis HN019 in Oral Diseases" International Journal of Molecular Sciences 23, no. 16: 9334. https://doi.org/10.3390/ijms23169334

APA Style

Araujo, L. D. C., Furlaneto, F. A. C., da Silva, L. A. B., & Kapila, Y. L. (2022). Use of the Probiotic Bifidobacterium animalis subsp. lactis HN019 in Oral Diseases. International Journal of Molecular Sciences, 23(16), 9334. https://doi.org/10.3390/ijms23169334

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