Thebromine Targets Adenosine Receptors to Control Hippocampal Neuronal Function and Damage
Abstract
:1. Introduction
2. Results
2.1. Theobromine Bolsters Basal Synaptic Transmission and Impairs Long-Term Potentiation
2.2. The Effect of Theobromine on Synaptic Transmission and Plasticity Is Lost upon Removal of Extracellular Adenosine
2.3. Theobromine Bolsters Synaptic Transmission through the Antagonism of A1R
2.4. Theobromine Impairs Synaptic Plasticity through the Antagonism of A2AR
2.5. Theobromine and Caffeine Abrogate the Impairment of Synaptic Plasticity and Neuronal Viability Triggered by β-Amyloid Peptides
3. Discussion
4. Methods and Materials
4.1. Ethical Approval
4.2. Animals
4.3. Drugs
4.4. Extracellular Electrophysiological Recordings
4.5. Cell Culture
4.6. Peptide Treatment and Immunocytochemistry
4.7. Statistics
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Valada, P.; Alçada-Morais, S.; Cunha, R.A.; Lopes, J.P. Thebromine Targets Adenosine Receptors to Control Hippocampal Neuronal Function and Damage. Int. J. Mol. Sci. 2022, 23, 10510. https://doi.org/10.3390/ijms231810510
Valada P, Alçada-Morais S, Cunha RA, Lopes JP. Thebromine Targets Adenosine Receptors to Control Hippocampal Neuronal Function and Damage. International Journal of Molecular Sciences. 2022; 23(18):10510. https://doi.org/10.3390/ijms231810510
Chicago/Turabian StyleValada, Pedro, Sofia Alçada-Morais, Rodrigo A. Cunha, and João Pedro Lopes. 2022. "Thebromine Targets Adenosine Receptors to Control Hippocampal Neuronal Function and Damage" International Journal of Molecular Sciences 23, no. 18: 10510. https://doi.org/10.3390/ijms231810510