Metabolic and Proteomic Profiles Associated with Immune Responses Induced by Different Inactivated SARS-CoV-2 Vaccine Candidates
Abstract
:1. Introduction
2. Results
2.1. Immunogenicity Analysis
2.2. Metabolic Profiles
2.3. Proteomic Profiles
3. Discussion
4. Materials and Methods
4.1. Vaccine
4.2. Animal Models
4.3. Neutralization Assay
4.4. Flow Cytometry
4.5. ELISPOT Assay
4.6. Metabolic Analysis
4.7. Proteomic Analysis
4.8. Statistics
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Experiment | Group | Total Number | Male | Female |
---|---|---|---|---|
Neutralization analysis | HB02 | 10 | 5 | 5 |
Delta | 10 | 5 | 5 | |
Omicron | 10 | 5 | 5 | |
Immunoassay (FACS, ELISPOT) | HB02 | 6 | 3 | 3 |
Delta | 6 | 3 | 3 | |
Omicron | 6 | 3 | 3 | |
Omic analysis | HB02 | 5 | 3 | 2 |
Delta | 5 | 3 | 2 | |
Omicron | 5 | 3 | 2 |
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Yu, S.; He, Y.; Ji, W.; Yang, R.; Zhao, Y.; Li, Y.; Liu, Y.; Ding, L.; Ma, M.; Wang, H.; et al. Metabolic and Proteomic Profiles Associated with Immune Responses Induced by Different Inactivated SARS-CoV-2 Vaccine Candidates. Int. J. Mol. Sci. 2022, 23, 10644. https://doi.org/10.3390/ijms231810644
Yu S, He Y, Ji W, Yang R, Zhao Y, Li Y, Liu Y, Ding L, Ma M, Wang H, et al. Metabolic and Proteomic Profiles Associated with Immune Responses Induced by Different Inactivated SARS-CoV-2 Vaccine Candidates. International Journal of Molecular Sciences. 2022; 23(18):10644. https://doi.org/10.3390/ijms231810644
Chicago/Turabian StyleYu, Shouzhi, Yao He, Wenheng Ji, Rong Yang, Yuxiu Zhao, Yan Li, Yingwei Liu, Ling Ding, Meng Ma, Hui Wang, and et al. 2022. "Metabolic and Proteomic Profiles Associated with Immune Responses Induced by Different Inactivated SARS-CoV-2 Vaccine Candidates" International Journal of Molecular Sciences 23, no. 18: 10644. https://doi.org/10.3390/ijms231810644