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Volume 23
Issue 2
10.3390/ijms23020962
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Review
Peer-Review Record

Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues

Int. J. Mol. Sci. 2022, 23(2), 962; https://doi.org/10.3390/ijms23020962
by Xingzhi Wang 1,†, Nitesh Tewari 2,†, Fuyuki Sato 3, Keiji Tanimoto 4, Lakshmi Thangavelu 5, Makoto Makishima 1,* and Ujjal K. Bhawal 5,6,*
Reviewer 1:
John W. Nicholson
Reviewer 2: Anonymous
Reviewer 3: Anonymous
Int. J. Mol. Sci. 2022, 23(2), 962; https://doi.org/10.3390/ijms23020962
Submission received: 20 December 2021 / Revised: 12 January 2022 / Accepted: 13 January 2022 / Published: 16 January 2022
(This article belongs to the Special Issue Gene Expression and Molecular Targets of Oral Cancer and Periodontal Diseases)

Round 1

Reviewer 1 Report

This paper reviews the clinical use of fluoride in the form of NaF, with extensive reference to the published literature (132 citations overall).  As such, it is both sound and comprehensive.  The article considers the differences in behaviour of high and low concentrations of fluoride, and shows that the latter are generally beneficial, whereas the former and generally damaging.   The reasons for these differences in terms of differences in cellular and/or metabolic mechanisms are described in detail.   Overall, this is a very useful and timely review, and sums up our current state of knowledge extremely well.

The English is of a very high standard, and I have only two minor suggestions for improvement, as follows:

Line 110: The word "is" should be "are", and the number "4" should be replaced by the word "four".

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

Very  fine paper, well structured. Please check minor spelling and grammar corrections. Well done!

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 3 Report

Manuscript does not conform to the scientific model of publications and in this form does not bring anything new to current knowledge.
A major revision must be carried out for it to be published.

In my opinion, we need to change the focus of the review and also evaluate the alternative substances to fluoride that can benefit dental and periodontal tissues.
I enclose the reference:

 

SEM/EDS Evaluation of the Mineral Deposition on a Polymeric Composite Resin of a Toothpaste Containing Biomimetic Zn-Carbonate Hydroxyapatite (microRepair®) in Oral Environment: A Randomized Clinical Trial
Polymers2021, 13(16), 2740

Reformulating the abstract too thin without adding anything new

Incorporate the Pico model into materials and methods and broaden the discussion with alternative approaches to fluoride

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Round 2

Reviewer 3 Report

The manuscript has been correctly revised, you can proceed to publication

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