Next Article in Journal
Cardiac Disease Alters Myocardial Tissue Levels of Epoxyeicosatrienoic Acids and Key Proteins Involved in Their Biosynthesis and Degradation
Next Article in Special Issue
A Case-Control Study on the Changes in High-Sensitivity C-Reactive Protein and Tumor Necrosis Factor-Alpha Levels with Surgical Treatment of OSAS
Previous Article in Journal
Comparative Genomic and Expression Analysis Insight into Evolutionary Characteristics of PEBP Genes in Cultivated Peanuts and Their Roles in Floral Induction
Previous Article in Special Issue
Obstructive Sleep Apnea Syndrome In Vitro Model: Controlled Intermittent Hypoxia Stimulation of Human Stem Cells-Derived Cardiomyocytes
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 23
Issue 20
10.3390/ijms232012431
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

CPAP Influence on Readily Available Inflammatory Markers in OSA—A Pilot Study

by
Ioana Madalina Zota
1,
Cristina Andreea Adam
1,
Dragoș Traian Marius Marcu
1,
Cristian Stătescu
1,
Radu Sascău
1,
Larisa Anghel
1,
Daniela Boișteanu
2,
Mihai Roca
1,
Corina Lucia Dima Cozma
1,*,
Alexandra Maștaleru
1,
Maria Magdalena Leon Constantin
1,*,
Elena Andreea Moaleș
2 and
Florin Mitu
1
1
Department of Medical Specialties (I), Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iași, Romania
2
Department of Medical Specialties (III), Faculty of Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iași, Romania
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(20), 12431; https://doi.org/10.3390/ijms232012431
Submission received: 10 September 2022 / Revised: 7 October 2022 / Accepted: 14 October 2022 / Published: 17 October 2022
(This article belongs to the Special Issue Sleep Apnea and Systemic Inflammation)
Browse Figures
Review Reports Versions Notes

Abstract

Obstructive sleep apnea (OSA) is characterized by repetitive upper airway collapse, chronic hypoxia and a proinflammatory phenotype. The purpose of our study was to evaluate readily available inflammatory biomarkers (C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cell count (WBC), red cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume (MPV), WBC-to-MPV ratio (WMR) and lymphocyte-to-C-reactive protein ratio (LCR)) before and after CPAP in patients with moderate–severe OSA. We performed a prospective study that included patients with newly-diagnosed moderate–severe OSA. The control groups (patients without OSA and with mild OSA) were selected from the hospital polygraphy database. All subjects underwent routine blood panel, which was repeated in moderate–severe OSA patients after 8 weeks of CPAP. Our final study group included 31 controls, 33 patients with mild, 22 patients with moderate and 37 patients with severe OSA. CRP, ESR, NLR and WMR were correlated with OSA severity. After 8-week CPAP therapy, we documented a decrease in weight status, which remained statistically significant in both CPAP-adherent and non-adherent subgroups. Readily available, inexpensive inflammatory parameters can predict the presence of moderate–severe OSA, but are not influenced by short-term CPAP.
Keywords: obstructive sleep apnea (OSA); continuous positive airway pressure (CPAP); inflammation; C-reactive protein (CRP); red cell distribution width (RDW); neutrophil-to-lymphocyte ratio (NLR); platelet-to-lymphocyte ratio (PLR) obstructive sleep apnea (OSA); continuous positive airway pressure (CPAP); inflammation; C-reactive protein (CRP); red cell distribution width (RDW); neutrophil-to-lymphocyte ratio (NLR); platelet-to-lymphocyte ratio (PLR)

Share and Cite

MDPI and ACS Style

Zota, I.M.; Adam, C.A.; Marcu, D.T.M.; Stătescu, C.; Sascău, R.; Anghel, L.; Boișteanu, D.; Roca, M.; Cozma, C.L.D.; Maștaleru, A.; et al. CPAP Influence on Readily Available Inflammatory Markers in OSA—A Pilot Study. Int. J. Mol. Sci. 2022, 23, 12431. https://doi.org/10.3390/ijms232012431

AMA Style

Zota IM, Adam CA, Marcu DTM, Stătescu C, Sascău R, Anghel L, Boișteanu D, Roca M, Cozma CLD, Maștaleru A, et al. CPAP Influence on Readily Available Inflammatory Markers in OSA—A Pilot Study. International Journal of Molecular Sciences. 2022; 23(20):12431. https://doi.org/10.3390/ijms232012431

Chicago/Turabian Style

Zota, Ioana Madalina, Cristina Andreea Adam, Dragoș Traian Marius Marcu, Cristian Stătescu, Radu Sascău, Larisa Anghel, Daniela Boișteanu, Mihai Roca, Corina Lucia Dima Cozma, Alexandra Maștaleru, and et al. 2022. "CPAP Influence on Readily Available Inflammatory Markers in OSA—A Pilot Study" International Journal of Molecular Sciences 23, no. 20: 12431. https://doi.org/10.3390/ijms232012431

APA Style

Zota, I. M., Adam, C. A., Marcu, D. T. M., Stătescu, C., Sascău, R., Anghel, L., Boișteanu, D., Roca, M., Cozma, C. L. D., Maștaleru, A., Constantin, M. M. L., Moaleș, E. A., & Mitu, F. (2022). CPAP Influence on Readily Available Inflammatory Markers in OSA—A Pilot Study. International Journal of Molecular Sciences, 23(20), 12431. https://doi.org/10.3390/ijms232012431

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop