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Article

The Transcriptomic Landscape of Pediatric Astrocytoma

by
Abrahan Hernández-Hernández
1,2,*,†,
Tayde López-Santaella
1,2,
Aranxa Torres-Caballero
1,2,
Amarantha Serrato
1,2,
Ulises Torres-Flores
1,2,
Diego Montesinos-Valencia
1,2,
Fernando Chico-Ponce de León
3,
Vicente González-Carranza
3,
Samuel Torres-García
3,
Rosa Rebollar-Vega
4,
Inti Alberto De la Rosa-Velázquez
4,‡,
Rosario Ortiz
5,
Monserrat Pérez-Ramírez
6,
Normand García-Hernández
6,
Antonio García-Méndez
7 and
Francisco Arenas-Huertero
2,*
1
Biología de Células Individuales (BIOCELIN), Hospital Infantil de México Federico Gómez, Ciudad de México 06720, Mexico
2
Laboratorio de Investigación en Patología Experimental, Hospital Infantil de México Federico Gómez, Ciudad de México 06720, Mexico
3
Departamento de Neurología, Hospital Infantil de México Federico Gómez, Ciudad de México 06720, Mexico
4
Laboratorio de Genómica, Red de Apoyo a la Investigación, Universidad Nacional Autónoma de México, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México City 04510, Mexico
5
Laboratorio de Microscopía Electrónica, Facultad de Ciencias, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico
6
Unidad de Investigación Médica en Genética Humana, Centro Médico Nacional Siglo XXI, IMSS, Hospital de Pediatría, Ciudad de México 06720, Mexico
7
Centro Médico Nacional, La Raza, IMSS, Hospital General Gaudencio González Garza, Ciudad de México 04510, Mexico
*
Authors to whom correspondence should be addressed.
†
Current address: Department of Cell and Molecular Biology, Karolinska Institutet, 17177 Stockholm, Sweden.
‡
Current address: Genomics Core Facility, Helmholtz Zentrum München, 85764 München, Germany.
Int. J. Mol. Sci. 2022, 23(20), 12696; https://doi.org/10.3390/ijms232012696
Submission received: 1 September 2022 / Revised: 29 September 2022 / Accepted: 11 October 2022 / Published: 21 October 2022
(This article belongs to the Special Issue State-of-the-Art Molecular Oncology in Mexico)
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Abstract

Central nervous system tumors are the most common solid neoplasia during childhood and represent one of the leading causes of cancer-related mortality. Tumors arising from astrocytic cells (astrocytomas) are the most frequently diagnosed, and according to their histological and pathological characteristics, they are classified into four categories. However, an additional layer of molecular classification considering the DNA sequence of the tumorigenesis-associated genes IDH1/2 and H3F3A has recently been incorporated into the classification guidelines. Although mutations in H3F3A are found exclusively in a subtype of grade IV pediatric astrocytoma, mutations in IDH1/2 genes are very rare in children under 14 years of age. The transcriptomic profiles of astrocytoma in adults and children have been extensively studied. However, there is scarce information on these profiles in pediatric populations considering the status of tumorigenesis-associated genes. Therefore, here we report the transcriptomic landscape of the four grades of pediatric astrocytoma by RNA sequencing. We found several well-documented biological functions associated with the misregulated genes in the four grades of astrocytoma, as well as additional biological pathways. Among the four grades of astrocytoma, we found shared misregulated genes that could have implications in tumorigenesis. Finally, we identified a transcriptional signature for almost all grades of astrocytoma that could be used as a transcription-based identification method.
Keywords: pediatric astrocytoma; transcriptome; RNA-seq pediatric astrocytoma; transcriptome; RNA-seq

Share and Cite

MDPI and ACS Style

Hernández-Hernández, A.; López-Santaella, T.; Torres-Caballero, A.; Serrato, A.; Torres-Flores, U.; Montesinos-Valencia, D.; Chico-Ponce de León, F.; González-Carranza, V.; Torres-García, S.; Rebollar-Vega, R.; et al. The Transcriptomic Landscape of Pediatric Astrocytoma. Int. J. Mol. Sci. 2022, 23, 12696. https://doi.org/10.3390/ijms232012696

AMA Style

Hernández-Hernández A, López-Santaella T, Torres-Caballero A, Serrato A, Torres-Flores U, Montesinos-Valencia D, Chico-Ponce de León F, González-Carranza V, Torres-García S, Rebollar-Vega R, et al. The Transcriptomic Landscape of Pediatric Astrocytoma. International Journal of Molecular Sciences. 2022; 23(20):12696. https://doi.org/10.3390/ijms232012696

Chicago/Turabian Style

Hernández-Hernández, Abrahan, Tayde López-Santaella, Aranxa Torres-Caballero, Amarantha Serrato, Ulises Torres-Flores, Diego Montesinos-Valencia, Fernando Chico-Ponce de León, Vicente González-Carranza, Samuel Torres-García, Rosa Rebollar-Vega, and et al. 2022. "The Transcriptomic Landscape of Pediatric Astrocytoma" International Journal of Molecular Sciences 23, no. 20: 12696. https://doi.org/10.3390/ijms232012696

APA Style

Hernández-Hernández, A., López-Santaella, T., Torres-Caballero, A., Serrato, A., Torres-Flores, U., Montesinos-Valencia, D., Chico-Ponce de León, F., González-Carranza, V., Torres-García, S., Rebollar-Vega, R., De la Rosa-Velázquez, I. A., Ortiz, R., Pérez-Ramírez, M., García-Hernández, N., García-Méndez, A., & Arenas-Huertero, F. (2022). The Transcriptomic Landscape of Pediatric Astrocytoma. International Journal of Molecular Sciences, 23(20), 12696. https://doi.org/10.3390/ijms232012696

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