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Volume 23
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Article

Antipsychotic Drug-Mediated Adverse Effects on Rat Testicles May Be Caused by Altered Redox and Hormonal Homeostasis

by
Aleksandra Nikolić-Kokić
1,*,
Nikola Tatalović
1,
Jelena Brkljačić
2,
Milica Mijović
3,
Vojkan Nestorović
4,
Ana Mijušković
1,
Zorana Oreščanin-Dušić
1,
Teodora Vidonja Uzelac
1,
Milan Nikolić
5,
Snežana Spasić
6,
Duško Blagojević
1 and
Čedo Miljević
7
1
Department of Physiology, Institute for Biological Research “Siniša Stanković”—National Institute of Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia
2
Department of Biochemistry, Institute for Biological Research “Siniša Stanković”—National Institute of Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia
3
Institute of Pathology, Faculty of Medicine, University of Priština, 38220 Kosovska Mitrovica, Serbia
4
Institute of Physiology, Faculty of Medicine, University of Priština, 38220 Kosovska Mitrovica, Serbia
5
Department of Biochemistry, Faculty of Chemistry, University of Belgrade, 11000 Belgrade, Serbia
6
Department of Chemistry, Institute of Chemistry, Technology and Metallurgy–National Institute of Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia
7
Outpatient Department, Institute of Mental Health, School of Medicine, University of Belgrade, 11000 Belgrade, Serbia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(22), 13698; https://doi.org/10.3390/ijms232213698
Submission received: 22 September 2022 / Revised: 29 October 2022 / Accepted: 3 November 2022 / Published: 8 November 2022
(This article belongs to the Special Issue Redox Physiology in Biomedicine and Ecophysology: Influence of Various Substances in Redox Regulation of Cell Metabolism)
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Abstract

Sexual dysfunction, as a noticeable adverse effect of atypical antipsychotic drugs (APDs) for the treatment of schizophrenia, has not been investigated in detail. A study was undertaken to investigate whether 28-day long treatment with clozapine, ziprasidone or sertindole (using a recommended daily dose for atypical antipsychotic therapy), induced histopathological changes both in rat testicles and prostate, changed the activity of the antioxidant defence system and altered blood testosterone and prolactin. Clozapine, ziprasidone and sertindole induced histopathological changes in rat testicular tissue, which could be attributed to a disturbed testicular antioxidant defence system in addition to an altered prolactin to testosterone ratio. None of the APD treatments induced histopathological changes in prostate. Our results demonstrate that APDs have the capacity to change both redox and endocrinological balance. One or both outcomes could underline testicular degeneration and disturbed spermatogenesis.
Keywords: testicles; prostate; atypical antipsychotics; antioxidant enzymes testicles; prostate; atypical antipsychotics; antioxidant enzymes

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MDPI and ACS Style

Nikolić-Kokić, A.; Tatalović, N.; Brkljačić, J.; Mijović, M.; Nestorović, V.; Mijušković, A.; Oreščanin-Dušić, Z.; Vidonja Uzelac, T.; Nikolić, M.; Spasić, S.; et al. Antipsychotic Drug-Mediated Adverse Effects on Rat Testicles May Be Caused by Altered Redox and Hormonal Homeostasis. Int. J. Mol. Sci. 2022, 23, 13698. https://doi.org/10.3390/ijms232213698

AMA Style

Nikolić-Kokić A, Tatalović N, Brkljačić J, Mijović M, Nestorović V, Mijušković A, Oreščanin-Dušić Z, Vidonja Uzelac T, Nikolić M, Spasić S, et al. Antipsychotic Drug-Mediated Adverse Effects on Rat Testicles May Be Caused by Altered Redox and Hormonal Homeostasis. International Journal of Molecular Sciences. 2022; 23(22):13698. https://doi.org/10.3390/ijms232213698

Chicago/Turabian Style

Nikolić-Kokić, Aleksandra, Nikola Tatalović, Jelena Brkljačić, Milica Mijović, Vojkan Nestorović, Ana Mijušković, Zorana Oreščanin-Dušić, Teodora Vidonja Uzelac, Milan Nikolić, Snežana Spasić, and et al. 2022. "Antipsychotic Drug-Mediated Adverse Effects on Rat Testicles May Be Caused by Altered Redox and Hormonal Homeostasis" International Journal of Molecular Sciences 23, no. 22: 13698. https://doi.org/10.3390/ijms232213698

APA Style

Nikolić-Kokić, A., Tatalović, N., Brkljačić, J., Mijović, M., Nestorović, V., Mijušković, A., Oreščanin-Dušić, Z., Vidonja Uzelac, T., Nikolić, M., Spasić, S., Blagojević, D., & Miljević, Č. (2022). Antipsychotic Drug-Mediated Adverse Effects on Rat Testicles May Be Caused by Altered Redox and Hormonal Homeostasis. International Journal of Molecular Sciences, 23(22), 13698. https://doi.org/10.3390/ijms232213698

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