Transcription Factors as Targets of Natural Compounds in Age-Related Diseases and Cancer: Potential Therapeutic Applications
Abstract
:1. Introduction
2. Oxidative Stress, Inflammation, and Aging
3. Effects of Natural Compound-Mediated SIRT1 on Diabetes
4. Anti-Inflammation Effects of Green Tea in Aging
5. Effect of Resveratrol through SIRT1/FoxO Signaling in Age-Related Diseases
6. Effects of Natural Compounds on Liver Cancer and Other Tumors
7. Ferulate from Rice Modulates NFκB Signaling
8. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Compounds | Chemical Structures | Compounds | Chemical Structures |
---|---|---|---|
Carotenoids | Gentiopicroside | ||
catechins | epicatechin | ||
epicatechin-3-gallate | epigallocatechin | ||
Resveratrol | quercetin | ||
Fisetin | Apigenin | ||
Vanillin | Spiropachysine A | ||
Deoxyelephantopin | Chlorogenic acid | ||
Genistein | Ferulic acid |
Factor | Aging or Diseases | Natural Compounds | References | |
---|---|---|---|---|
Cytokines | TNF-α | ↑ | ├ | [51] |
IL-1β | ↑ | ├ | [69] | |
IL-6 | ↑ | ├ | [127] | |
Chemokines | IL-2 | ↓ | ├ | [59] |
IL-10 | ↓ | ├ | [51] | |
Transcription factors | NRF2 | ↑ | ├ | [89,109] |
NF-κB | ↑ | ├ | [53,54] | |
SIRT1 | ↓ | ├ | [77,78] | |
FoxO | ↑ | ├ | [91] | |
Signaling | MARK4 | ↑ | ├ | [103,104] |
Ras/Rac1 | ↑ | ├ | [105] | |
ERK | ↑ | ├ | [55,107] | |
Akt | ↑ | ├ | [85,112] | |
AMPK | ↓ | ├ | [65] |
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Kim, M.E.; Kim, D.H.; Lee, J.S. Transcription Factors as Targets of Natural Compounds in Age-Related Diseases and Cancer: Potential Therapeutic Applications. Int. J. Mol. Sci. 2022, 23, 13882. https://doi.org/10.3390/ijms232213882
Kim ME, Kim DH, Lee JS. Transcription Factors as Targets of Natural Compounds in Age-Related Diseases and Cancer: Potential Therapeutic Applications. International Journal of Molecular Sciences. 2022; 23(22):13882. https://doi.org/10.3390/ijms232213882
Chicago/Turabian StyleKim, Mi Eun, Dae Hyun Kim, and Jun Sik Lee. 2022. "Transcription Factors as Targets of Natural Compounds in Age-Related Diseases and Cancer: Potential Therapeutic Applications" International Journal of Molecular Sciences 23, no. 22: 13882. https://doi.org/10.3390/ijms232213882