Neural Regulations in Tooth Development and Tooth–Periodontium Complex Homeostasis: A Literature Review
Abstract
:1. Introduction
2. Anatomical and Embryological Basis
3. Tooth Influences Neurophysiology during Development Process
3.1. Tooth Innervation Is Spatiotemporally Regulated
3.2. The Molecular Guidance Cues for Tooth–Periodontium Innervation
3.2.1. Neurotrophins
3.2.2. Semaphorins
3.3. Related Application in Tooth Regeneration
4. The Nervous System Regulates Tooth Development
4.1. Neural Regulations in Tooth Development at Pre-Eruptive Stage
4.2. Neural Regulations in Tooth Eruption
4.3. Related Application in Tooth Regeneration
5. Dental Disease Causes Neurophysiological Changes
5.1. Morphological Changes in Local Dental Nerves
5.2. Molecular Changes in Neural Cells
5.3. Related Application in Tooth Regeneration
6. The Nervous System Influences the Pathology of Dental Diseases
6.1. SP
6.2. VIP
6.3. ACh and Cholinergic System
6.4. PACAP
6.5. NPY
6.6. CGRP
6.7. CNS-Released Neurohormones
6.8. Related Applications in Tooth Regeneration
7. The Nervous System Regulates Dental Stem Cells
7.1. Neural Regulations and Incisor Stem Cells
7.2. PNS-Derived Neuropeptides on Dental Stem Cells
7.3. The Role of Peripheral Non-Neuron Cells in Dental Stem Cells
7.4. CNS-Released Neurohormones and Stem Cells
7.5. Related Application in Tooth Regeneration
8. Conclusions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Nerve Fibers | Regional Distribution | Function |
---|---|---|
sensory | Raschkow plexus Throughout the pulp In the dentinal tubule | Highly specialized nociceptors |
sympathetic | SCG→TG→sensory fibers→pulp SCG→inferior/superior alveolar artery→pulp Around pulp arterioles Raschkow plexus | Regulate pulp blood flow |
Nerve Fibers | Regional Distribution | Function |
---|---|---|
sensory | Throughout the PDL As bundles around blood vessels near the alveolar bone As free endings near the cementum | Nociceptors and mechanoreceptors Regulate blood flow |
autonomic | Few | Regulate blood flow |
Stem cells | Neural Regulations | Biological Effects | Molecular Mechanism | Ref. |
---|---|---|---|---|
MSCs (Incisor) | IAN secretion | Promoting MSC proliferation | Wnt signaling | [149] |
Sustaining Gli1 expression and odontogenic commitment of MSCs | Shh signaling | [149] | ||
SCs/SCPs | Giving rise to MSCs that generate odontoblasts and pulp cells | SCs and SCPs differentiation | [150] | |
ESCs (Incisor) | IAN | Regulating ESC niches and differentiation | Mesenchymal–epithelial interaction | [13] |
DPSCs | Shh & CGRP | Shh promotes odontoblastic differentiation and CGRP promotes proliferation of DPSCs | CGRP/Shh signaling | [125] |
SC-EVs | Promoting DPSC multipotency | Oct4/Sox2/Nanog | [151] | |
Promoting DPSC proliferation | TGF-β/Smad signaling TGF-β/MAPK signaling | [151] | ||
Promoting DPSC migration and osteogenic differentiation | SDF-1/CXCR4 | [152] | ||
Melatonin (intermediate concentration) | Promoting DPSC proliferation and osteogenic differentiation | COX-2/NF-κB signaling p38/ERK MAPK signaling | [153] | |
Promoting DPSC migration and proliferation | - | [154] | ||
Increasing TGF-b production by DPSCs to suppress T-cell proliferation upon stimuli | - | [154] | ||
Promoting DPSC osteogenic differentiation | Suppressing DNA methylation | [155] | ||
Melatonin (low concentration) | Inhibiting DPSC proliferation and inducing DPSC neuronal differentiation | Hippo pathway | [156] | |
PDLSCs | SP | PDLSCs produce CCL20/MIP-3α to recruit T cells | p38 and ERK/MAPK signaling | [157] |
SP | Promoting PDLSC osteogenic differentiation | SP/HO-1/Nrf-2 | [158] | |
NPY | Moderate osteogenic effects | - | [117] | |
SCs | Promoting osteogenic differentiation of PDLSCs | ERK1/2 signaling | [159] | |
Melatonin (low concentration) | Rejuvenating long-term ex vivo expanded PDLSCs by restoring their autophagy | PI3K/AKT/mTOR signaling | [160] | |
Suppressing PDLSC osteogenic differentiation | Increasing mitochondrial fission | [161] | ||
BMSCs | Melatonin (intermediate concentration) | Promoting BMSCs osteogenic differentiation | AMPK/FOXO3a/RUNX2 signaling | [162] |
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Duan, Y.; Liang, Y.; Yang, F.; Ma, Y. Neural Regulations in Tooth Development and Tooth–Periodontium Complex Homeostasis: A Literature Review. Int. J. Mol. Sci. 2022, 23, 14150. https://doi.org/10.3390/ijms232214150
Duan Y, Liang Y, Yang F, Ma Y. Neural Regulations in Tooth Development and Tooth–Periodontium Complex Homeostasis: A Literature Review. International Journal of Molecular Sciences. 2022; 23(22):14150. https://doi.org/10.3390/ijms232214150
Chicago/Turabian StyleDuan, Yihong, Yongfeng Liang, Fangyi Yang, and Yuanyuan Ma. 2022. "Neural Regulations in Tooth Development and Tooth–Periodontium Complex Homeostasis: A Literature Review" International Journal of Molecular Sciences 23, no. 22: 14150. https://doi.org/10.3390/ijms232214150