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Volume 23
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10.3390/ijms232214445
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Review

BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions

by
Susana Cubillos
1,
Olivia Engmann
1,* and
Anna Brancato
2
1
Institute for Biochemistry and Biophysics, Friedrich-Schiller-University Jena, 07745 Jena, Germany
2
Department of Sciences for Health Promotion and Mother and Child Care “G. D’Alessandro”, University of Palermo, 90127 Palermo, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(22), 14445; https://doi.org/10.3390/ijms232214445
Submission received: 12 October 2022 / Revised: 8 November 2022 / Accepted: 16 November 2022 / Published: 21 November 2022
(This article belongs to the Special Issue Recent Advances in Antidepressants and Mood-Stabilizing Drugs)
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Abstract

Conventional antidepressants are widely employed in several psychiatric and neurologic disorders, yet the mechanisms underlying their delayed and partial therapeutic effects are only gradually being understood. This narrative review provides an up-to-date overview of the interplay between antidepressant treatment and Brain-Derived Neurotrophic Factor (BDNF) signaling. In addition, the impact of nutritional, environmental and physiological factors on BDNF and the antidepressant response is outlined. This review underlines the necessity to include information on lifestyle choices in testing and developing antidepressant treatments in the future.
Keywords: antidepressants; depression; BDNF; TrkB; environment antidepressants; depression; BDNF; TrkB; environment

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MDPI and ACS Style

Cubillos, S.; Engmann, O.; Brancato, A. BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions. Int. J. Mol. Sci. 2022, 23, 14445. https://doi.org/10.3390/ijms232214445

AMA Style

Cubillos S, Engmann O, Brancato A. BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions. International Journal of Molecular Sciences. 2022; 23(22):14445. https://doi.org/10.3390/ijms232214445

Chicago/Turabian Style

Cubillos, Susana, Olivia Engmann, and Anna Brancato. 2022. "BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions" International Journal of Molecular Sciences 23, no. 22: 14445. https://doi.org/10.3390/ijms232214445

APA Style

Cubillos, S., Engmann, O., & Brancato, A. (2022). BDNF as a Mediator of Antidepressant Response: Recent Advances and Lifestyle Interactions. International Journal of Molecular Sciences, 23(22), 14445. https://doi.org/10.3390/ijms232214445

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