Human Umbilical Cord-Based Therapeutics: Stem Cells and Blood Derivatives for Female Reproductive Medicine
, María Gómez-Álvarez 1,†, Emilio Francés-Herrero 1,3, Mónica Romeu 4, Hortensia Ferrero 1,‡, Emre Seli 2,5,‡ and Irene Cervelló 1,*,‡Round 1
Reviewer 1 Report
The review by Rodríguez-Eguren et al, describes the available therapeutic options for female reproductive disorders using human umbilical cord blood derivatives. It is an overall well-written review with comprehensive coverage of pre-clinical research on use of hUC and MSC for treatment of human diseases.
Following are the comments:
1. Move the following appendices for the tables to the end of the text:
Line 275-280, Line 405-416, Line 524-539,
2. The content of Table 1 describing human diseases and not female reproductive disorders, does not fit into the scope of the review about treatment of reproductive disorders. I am not sure that it adds value to the review.
3. Table 2 and 3
Review and correct the format of titles to make it easily readable
4. In Table 2: In columns Ovarian morphology, developing follicles- describe the findings in few words. The arrows aren’t intuitive.
5. Are there any clinical trials using hUC for infertility treatments? If so, please include a table describing those.
6. I suggest making a table describing pros and cons if they can be easily contrasted. *Suggested- not required.
Author Response
Please, find attached the answers to the reviewer.
Author Response File: 
Author Response.pdf
Reviewer 2 Report
The manuscript by Eguren et. al, provides a comprehensive review of literature about human umbilical cord mesenchymal stem cells (hUC-MSC) along with their secreted paracrine factors and biomolecules as promising therapeutics in regenerative medicine. Overall, the manuscript is well written and will be very well-suited for publication in IJMS once the following comments are addressed:
1. Both the figures (Figure 1 and Figure 2) are poorly presented and convey very less information about the subject and needs to be improved.
2. The addition of a short summary regarding FDA approved cord blood treatments would strengthen the manuscript and authors conclusions.
Author Response
Please, find the responses to the queries and comments from the reviewer.
Author Response File: Author Response.pdf
