Candida Administration in 5/6 Nephrectomized Mice Enhanced Fibrosis in Internal Organs: An Impact of Lipopolysaccharide and (1→3)-β-D-Glucan from Leaky Gut

Round 1

Reviewer 1 Report

Dear Authors, 

Your manuscript ijms-2090197 'Candida administration in 5/6 nephrectomized mice enhanced fibrosis in internal organs, an impact of lipopolysaccharide and (1→3)-β-D-glucan from leaky gut ' is a very high quality research paper. It fits well the scope of the journal and is written in professional scientific  English. My only concern is the Conclusions section. It is too brief and my recommendation is to expand it. Also, it should be placed before Materials and Method. Minor revisions:

p. 1, 34: 'In vitro' should be italicized.

p. 2, 78 and elsewhere in the text: references should be grouped together: [14-20].

p. 9, first paragraph and elsewhere in the text: the choice of italicizing of some names is not clear.

I recommend acceptance of your MS after minor revisions.

Author Response

December 8^th, 2022

Dear editors and reviewers,

Re: Candida administration in 5/6 nephrectomized mice enhanced fibrosis in internal organs, an impact of lipopolysaccharide and (1→3)-β-D-glucan from leaky gut

Thank you for taking time to review out manuscript.

Please find our response to each review comment below.

Reviewer 1

Your manuscript ijms-2090197 'Candida administration in 5/6 nephrectomized mice enhanced fibrosis in internal organs, an impact of lipopolysaccharide and (1→3)-β-D-glucan from leaky gut ' is a very high quality research paper. It fits well the scope of the journal and is written in professional scientific English. My only concern is the Conclusions section. It is too brief and my recommendation is to expand it. Also, it should be placed before Materials and Method. I recommend acceptance of your MS after minor revisions.

We thank the reviewer for the comment. We have expanded the conclusion section as suggested.
The content of the article is ordered according to the journal’s format.

Minor revisions:

1. 1, 34: 'In vitro' should be italicized.
   p. 2, 78 and elsewhere in the text: references should be grouped together: [14-20].

We thank the reviewer for the suggestions and have corrected those accordingly.

1. 9, first paragraph and elsewhere in the text: the choice of italicizing of some names is not clear.

The genes names are italicized while the cytokine/protein names are not. We have rechecked the name italicizing, accordingly.

Thank you for your time to review our submission. Should you have any questions, please do not hesitate to contact me.

Kind regards,

Somkanya Tungsanga, on behalf of all authors.

Reviewer 2 Report

In the manuscript "Candida administration in 5/6 nephrectomized mice enhanced fibrosis in internal organs, an impact of lipopolysaccharide and (1-3)-β-D-glucan from leaky gut" authors showed that uremia-induced leaky gut causes the translocation of gut LPS and BG into circulation, which acti-vates the pro-inflammatory and pro-fibrotic pathways, causing internal organ fibrosis.

The manuscript is well written, and well organized with all necessary components and provides all background to the reader less familiar with the subject.

I support publication of this paper.

Author Response

December 8^th, 2022

Dear editors and reviewers,

Re: Candida administration in 5/6 nephrectomized mice enhanced fibrosis in internal organs, an impact of lipopolysaccharide and (1→3)-β-D-glucan from leaky gut

Thank you for taking time to review out manuscript.

Please find our response to each review comment below.

Reviewer 2

In the manuscript "Candida administration in 5/6 nephrectomized mice enhanced fibrosis in internal organs, an impact of lipopolysaccharide and (1-3)-β-D-glucan from leaky gut" authors showed that uremia-induced leaky gut causes the translocation of gut LPS and BG into circulation, which acti-vates the pro-inflammatory and pro-fibrotic pathways, causing internal organ fibrosis.
The manuscript is well written, and well organized with all necessary components and provides all background to the reader less familiar with the subject. I support publication of this paper.

We thank the reviewer for the comment.

Thank you for your time to review our submission. Should you have any questions, please do not hesitate to contact me.

Kind regards,

Somkanya Tungsanga, on behalf of all authors.