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Volume 23
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10.3390/ijms232416093
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Review

Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model

by
Heinig Leo
and
Markus Kipp
*
Institute of Anatomy, Rostock University Medical Center, 18057 Rostock, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(24), 16093; https://doi.org/10.3390/ijms232416093
Submission received: 17 November 2022 / Revised: 14 December 2022 / Accepted: 15 December 2022 / Published: 17 December 2022
(This article belongs to the Special Issue Morphology-Function Relationships of Neurons and Glia Cells)
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Abstract

Remyelination therapies, which are currently under development, have a great potential to delay, prevent or even reverse disability in multiple sclerosis patients. Several models are available to study the effectiveness of novel compounds in vivo, among which is the cuprizone model. This model is characterized by toxin-induced demyelination, followed by endogenous remyelination after cessation of the intoxication. Due to its high reproducibility and ease of use, this model enjoys high popularity among various research and industrial groups. In this review article, we will summarize recent findings using this model and discuss the potential of some of the identified compounds to promote remyelination in multiple sclerosis patients.
Keywords: cuprizone; multiple sclerosis; remyelination; demyelination; progression; protection cuprizone; multiple sclerosis; remyelination; demyelination; progression; protection

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MDPI and ACS Style

Leo, H.; Kipp, M. Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model. Int. J. Mol. Sci. 2022, 23, 16093. https://doi.org/10.3390/ijms232416093

AMA Style

Leo H, Kipp M. Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model. International Journal of Molecular Sciences. 2022; 23(24):16093. https://doi.org/10.3390/ijms232416093

Chicago/Turabian Style

Leo, Heinig, and Markus Kipp. 2022. "Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model" International Journal of Molecular Sciences 23, no. 24: 16093. https://doi.org/10.3390/ijms232416093

APA Style

Leo, H., & Kipp, M. (2022). Remyelination in Multiple Sclerosis: Findings in the Cuprizone Model. International Journal of Molecular Sciences, 23(24), 16093. https://doi.org/10.3390/ijms232416093

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