Modulation of Notch Signaling Pathway by Bioactive Dietary Agents
Abstract
:1. Introduction
2. Notch Signaling
3. Modulation of Notch Pathway by Dietary Agents
3.1. Curcumin
3.2. Genistein
3.3. EGCG and Tea Polyphenols
3.4. Resveratrol
3.5. Retinoic Acid
3.6. Sulforaphane
3.7. Vitamin D
3.8. Other Agents
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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↑ | Induced | ↓ | Suppressed | ||||||
---|---|---|---|---|---|---|---|---|---|
Dietary Agent | Cancer Type | Notch-1 | Notch-2 | Notch-3 | Jagged-1 | Hes-1 | Hey-1 | References | |
Curcumin | Cholangiocarcinoma | ↓ | ↓ | [30] | |||||
Colorectal *, # | ↓ | ↓ | [29,32] | ||||||
Esophageal | ↓ | ↓ | ↓ | [33] | |||||
Lymphoma | ↓ | [28] | |||||||
Osteosarcoma | ↓ | ↓ | ↓ | [31] | |||||
Prostate | ↓ | ↓ | [34] | ||||||
DATS | Osteosarcoma | ↓ | ↓ | [37] | |||||
Breast | ↓ | [38] | |||||||
Vitamin D | Breast * | ↓ | ↓ | ↓ | ↑ | [39] | |||
EGCG | Colorectal | ↑ | ↓ | ↓ | [40] | ||||
Head and Neck | ↓ | [41] | |||||||
Neuroblastoma | ↓ | [42] | |||||||
Tongue | ↓ | ↓ | ↓ | [43] | |||||
Genistein | Breast | ↓ | [44] | ||||||
Colon | ↓ | [45] | |||||||
Neuroblastoma | ↓ | ↓ | [46] | ||||||
Resveratrol | Cervical | ↓ | ↓ | ↓ | [47] | ||||
Carcinoids | ↑ | [48] | |||||||
Glioblastoma | ↑ | [49] | |||||||
Ovarian | ↓ | ↓ | [50] | ||||||
T-ALL | ↓ | ↓ | [51] | ||||||
Thyroid | ↑ | ↑ | [52] | ||||||
Retinoic Acid | Breast | ↓ | [53] | ||||||
Glioblastoma | ↓ | ↓ | [54] | ||||||
Neuroblastoma * | ↓ | [55] | |||||||
Ovarian | ↓ | [56] | |||||||
Pancreatic * | ↓ | [57] | |||||||
PEITC | Breast | ↓ | ↓ | [58] | |||||
Pancreatic | ↓ | ↓ | [59] | ||||||
Sulforaphane | Pancreatic | ↓ | [60] | ||||||
Prostate | ↓ | ↓ | [61] |
↑ | Induced | ↓ | Suppressed | |||||
---|---|---|---|---|---|---|---|---|
Dietary Agent | Concentration | Cancer Type | Effect | References | ||||
Curcumin | 0.2% equivalent curcuminoids as Meriva®, # | Colorectal | ↓ | NICD-1, Ki67 | [29] | |||
↑ | cleaved Caspase 3 | |||||||
↓ | tumor volume; additive effect on tumor volume with oxaliplatin | |||||||
Honokiol | 200 µg/kg body weight | Colorectal | ↓ | NICD-1, Jagged-1, Hes-1, Presenilin-1, Nicastrin | [62] | |||
↓ | tumor volume | |||||||
Sulforaphane | 6 µmol SFN in 0.1 mL PBS | Prostate | ↓ | NICD-2 | [63] | |||
EGCG | 25 mg/kg body weight | Lip, Tongue | ↓ | Notch-1, Notch-2, Hes1 | [43] | |||
Vitamin D | 10 mg/kg body weight of MT19c * | Ovarian | ↓ | Notch signaling pathway | [64] | |||
↑ | DNA fragmentation | |||||||
↓ | tumor volume |
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Kiesel, V.A.; Stan, S.D. Modulation of Notch Signaling Pathway by Bioactive Dietary Agents. Int. J. Mol. Sci. 2022, 23, 3532. https://doi.org/10.3390/ijms23073532
Kiesel VA, Stan SD. Modulation of Notch Signaling Pathway by Bioactive Dietary Agents. International Journal of Molecular Sciences. 2022; 23(7):3532. https://doi.org/10.3390/ijms23073532
Chicago/Turabian StyleKiesel, Violet A., and Silvia D. Stan. 2022. "Modulation of Notch Signaling Pathway by Bioactive Dietary Agents" International Journal of Molecular Sciences 23, no. 7: 3532. https://doi.org/10.3390/ijms23073532