Uncontrolled Thyroid during Pregnancy Alters the Circulative and Exerted Metabolome
Abstract
:1. Introduction
2. Results and Discussion
2.1. Circulatory Metabolome
2.2. Colostrum Metabolome
2.3. Receiver-Operating Characteristic (ROC) Curve Analysis for Metabolite Markers
2.4. MetabolitePathway Analysis
2.5. Metabolite–Disease Relation Network Analysis
3. Materials and Methods
3.1. Ethics Committee
3.2. Patients-Methods
3.3. Biofluid Collection
3.4. Metabolomic Analysis
Sample Preparation
3.5. NMR Analysis
3.6. Data Preprocessing
3.7. Annotation of Metabolites
3.8. Statistical Analysis
3.8.1. Postprocessing of Spectral Data
3.8.2. Identification of Important Features
3.8.3. Model Validation
3.8.4. Metabolic Pathways
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Fotakis, C.; Moros, G.; Kontogeorgou, A.; Iacovidou, N.; Boutsikou, T.; Zoumpoulakis, P. Uncontrolled Thyroid during Pregnancy Alters the Circulative and Exerted Metabolome. Int. J. Mol. Sci. 2022, 23, 4248. https://doi.org/10.3390/ijms23084248
Fotakis C, Moros G, Kontogeorgou A, Iacovidou N, Boutsikou T, Zoumpoulakis P. Uncontrolled Thyroid during Pregnancy Alters the Circulative and Exerted Metabolome. International Journal of Molecular Sciences. 2022; 23(8):4248. https://doi.org/10.3390/ijms23084248
Chicago/Turabian StyleFotakis, Charalambos, Giorgos Moros, Anna Kontogeorgou, Nicoletta Iacovidou, Theodora Boutsikou, and Panagiotis Zoumpoulakis. 2022. "Uncontrolled Thyroid during Pregnancy Alters the Circulative and Exerted Metabolome" International Journal of Molecular Sciences 23, no. 8: 4248. https://doi.org/10.3390/ijms23084248