Regulatory Roles of Caspase-11 Non-Canonical Inflammasome in Inflammatory Liver Diseases
Abstract
:1. Introduction
2. The Caspase-11 Non-Canonical Inflammasome
2.1. Structure and Activation of the Caspase-11 Non-Canonical Inflammasome
2.2. Caspase-11 Non-Canonical Inflammasome-Activated Signaling Pathways
3. Regulatory Roles of the Caspase-11 Non-Canonical Inflammasome in Inflammatory Liver Diseases
3.1. NAFLD
3.2. NASH
3.3. Inflammatory Liver Injury
4. Conclusions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
NAFLD | Non-alcoholic fatty liver disease |
NASH | Non-alcoholic steatohepatitis |
NLR | NOD-like receptor |
AIM2 | Absent in melanoma 2 |
CARD | Caspase recruit domain |
LPS | Lipopolysaccharide |
GSDMD | Gasdermin D |
PAMP | Pathogen-associated molecular pattern |
DAMP | Danger-associated molecular pattern |
SFD | Standard-fat diet |
HFD | High-fat diet |
BMDM | Bone-marrow-derived macrophage |
oxLDL | Oxidized low-density lipoprotein |
MCD | Methionine- and choline-deficient diet |
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Diseases | Roles | Models | Ref. |
NAFLD |
| Steatotic liver transplanted rats | [39] |
| HFD-fed obese rats | [40] | |
| HFD-fed obese mice | [41] | |
| HFD-fed obese and genetic-induced NAFLD mice | [42] | |
NASH |
| Ldlr−/− mice | [52] |
| LPS-injected obese mice | [56] | |
| MCD-treated mice | [57] | |
Inflammatory liver injury |
| LPS-injected mice | [64] |
| Hepatic IRI mice | [68] | |
| LPS-injected mice | [69] |
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Yi, Y.-S. Regulatory Roles of Caspase-11 Non-Canonical Inflammasome in Inflammatory Liver Diseases. Int. J. Mol. Sci. 2022, 23, 4986. https://doi.org/10.3390/ijms23094986
Yi Y-S. Regulatory Roles of Caspase-11 Non-Canonical Inflammasome in Inflammatory Liver Diseases. International Journal of Molecular Sciences. 2022; 23(9):4986. https://doi.org/10.3390/ijms23094986
Chicago/Turabian StyleYi, Young-Su. 2022. "Regulatory Roles of Caspase-11 Non-Canonical Inflammasome in Inflammatory Liver Diseases" International Journal of Molecular Sciences 23, no. 9: 4986. https://doi.org/10.3390/ijms23094986