Casein Kinase 2 Alpha Inhibition Protects against Sepsis-Induced Acute Kidney Injury
Abstract
:1. Introduction
2. Results
2.1. CK2α Expression Is Increased in Kidney Tissues of Septic AKI Mice
2.2. CK2α Inhibition Increases Survival Outcome of Spetic AKI Mice
2.3. CK2α Inhibition Protects Renal Function and Alleviates Kidney Injury
2.4. CK2α Inhibition Suppresses Apoptosis in Mice with Septic AKI
2.5. CK2α Inhibition Decreases Inflammatory Responses in Mice with Septic AKI
2.6. CK2α Inhibition Suppresses MAPK-NF-κB Signaling Pathway in Mice with Septic AKI
3. Discussion
4. Materials and Methods
4.1. Experimental Animals and Materials
4.2. Animal Model of Cecal Ligation & Puncture
4.3. Western Blot Analysis
4.4. Biochemical Analysis
4.5. Histopathologic Assessment
4.6. Immunohistochemistry
4.7. TUNEL Assay
4.8. Statistical Analysis
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Koo, J.-H.; Yu, H.C.; Nam, S.; Kim, D.-C.; Lee, J.H. Casein Kinase 2 Alpha Inhibition Protects against Sepsis-Induced Acute Kidney Injury. Int. J. Mol. Sci. 2023, 24, 9783. https://doi.org/10.3390/ijms24129783
Koo J-H, Yu HC, Nam S, Kim D-C, Lee JH. Casein Kinase 2 Alpha Inhibition Protects against Sepsis-Induced Acute Kidney Injury. International Journal of Molecular Sciences. 2023; 24(12):9783. https://doi.org/10.3390/ijms24129783
Chicago/Turabian StyleKoo, Jeung-Hyun, Hwang Chan Yu, Seonhwa Nam, Dong-Chan Kim, and Jun Ho Lee. 2023. "Casein Kinase 2 Alpha Inhibition Protects against Sepsis-Induced Acute Kidney Injury" International Journal of Molecular Sciences 24, no. 12: 9783. https://doi.org/10.3390/ijms24129783