Triangular Silver Nanoplates as a Bioanalytical Tool: Potential COVID-19 Detection
, Marija Mojicevic 1,*, Buket Alkan Tas 1, Miriam Huerta 2, Robert Pogue 3, Declan M. Devine 1 and Margaret Brennan-Fournet 1Round 1
Reviewer 1 Report
The article is well-written and well organized. The manuscript can be accepted for publication after minor corrections.
1. The abstract should be precise and compact.
2. The novelty of the present article should be included in the introduction section.
3. The authors are encouraged to modify the conclusion.
4. The English language should be carefully checked.
5. The authors may include some recent references to further broaden the scope.
1: Recent Advances in Plasma-Engineered Polymers for Biomarker-Based Viral Detection and Highly Multiplexed Analysis
2: kidney diseases and COVID-19 infection: causes and effect, supportive therapeutics and nutritional perspectives
The article is well-written and well organized. The manuscript can be accepted for publication after minor corrections.
1. The abstract should be precise and compact.
2. The novelty of the present article should be included in the introduction section.
3. The authors are encouraged to modify the conclusion.
4. The English language should be carefully checked.
5. The authors may include some recent references to further broaden the scope.
1: Recent Advances in Plasma-Engineered Polymers for Biomarker-Based Viral Detection and Highly Multiplexed Analysis
2: kidney diseases and COVID-19 infection: causes and effect, supportive therapeutics and nutritional perspectives
Author Response
Manuscript ID: ijms-2508206
We would like to thank the reviewers for their thoughtful review of the manuscript entitled " Triangular silver nanoplates as a bioanalytical tool: Potential COVID-19 Detection". The reviewers have raised important comments and we found their inputs to be very helpful for improving the quality of our manuscript.
We agree with most of their comments and the manuscript has been revised accordingly. Revised versions of the manuscript have been crafted with clearer highlights of the scope and the implications of our work than before. Moreover, the reviewers’ suggestions were included and marked in the text when needed.
We would like to raise the reviewers' awareness that the scope of our manuscript was to…
We are confident that the revised version of the manuscript has been improved and we anticipate that the reviewers will find our responses to their comments satisfactory.
Looking forward to hearing from you.
Best Regards
Marija Mojicevic
Referee: 1
Comments:
Comment 1. The abstract should be precise and compact.
Response 1. Thank you for this comment. We tried to make Abstract more compact and precise.
Comment 2. The novelty of the present article should be included in the introduction section.
Response 2. Your comment is greatly appreciated. The following statement was added in line 80 and the subsequent paragraph was modified to illustrate the method’s novelty.
“Specifically, triangular silver nanoparticles (TSNP) have appealing tunable plasmonic characteristics and have been used for biosensing applications. Furthermore, their optical profile has been reported to show the strongest and sharpest peaks among other metals (Rodriguez Barroso et al., 2023).”
Comment 3. The authors are encouraged to modify the conclusion.
Response 3. Thanks a lot for the observation. The conclusion was modified to aid in clarity and properly conclude the article’s approach.
Comment 4. The English language should be carefully checked.
Response 4. Thank you for this comment. We did our best to improve English.
Comment 5. The authors may include some recent references to further broaden the scope.
- Recent Advances in Plasma-Engineered Polymers for Biomarker-Based Viral Detection and Highly Multiplexed Analysis.
- Kidney diseases and COVID-19 infection: causes and effect, supportive therapeutics and nutritional perspectives
Response 5.
Proposed references have been included. Thank you for this suggestion.
Reviewer 2 Report
The manuscript "Triangular silver nanoplates as a bioanalytical tool: Potential 2 COVID-19 Detection" presents novel and promising results, definitely interesting for biophysics and biomedical society. The high sensitivity tool for immunoassays is clearly demonstrated. And in the view of recent threats, the potential platform for SARS-CoV-2 Spike protein detection makes this research valuable and in-time presented. The topic completely fulfills the journal scope and
the manuscript can be publish as is.
If talking about anything that can improve it, I would possibly avoid number of abbreviations in the abstract. More comprehensive terminology would attract a broader audience. And finally, the authors could make the conclusion more quantitative, including the most important numbers. For instance, how much the detection limits were improved as compared to the previous suggested techniques.
Author Response
Manuscript ID: ijms-2508206
We would like to thank the reviewers for their thoughtful review of the manuscript entitled " Triangular silver nanoplates as a bioanalytical tool: Potential COVID-19 Detection". The reviewers have raised important comments and we found their inputs to be very helpful for improving the quality of our manuscript.
We agree with most of their comments and the manuscript has been revised accordingly. Revised versions of the manuscript have been crafted with clearer highlights of the scope and the implications of our work than before. Moreover, the reviewers’ suggestions were included and marked in the text when needed.
We would like to raise the reviewers' awareness that the scope of our manuscript was to…
We are confident that the revised version of the manuscript has been improved and we anticipate that the reviewers will find our responses to their comments satisfactory.
Looking forward to hearing from you.
Best Regards
Marija Mojicevic
Referee: 2
Comments:
The manuscript "Triangular silver nanoplates as a bioanalytical tool: Potential 2 COVID-19 Detection" presents novel and promising results, definitely interesting for biophysics and biomedical society. The high sensitivity tool for immunoassays is clearly demonstrated. And in the view of recent threats, the potential platform for SARS-CoV-2 Spike protein detection makes this research valuable and in-time presented. The topic completely fulfills the journal scope and the manuscript can be publish as is.
If talking about anything that can improve it, I would possibly avoid number of abbreviations in the abstract. More comprehensive terminology would attract a broader audience. And finally, the authors could make the conclusion more quantitative, including the most important numbers. For instance, how much the detection limits were improved as compared to the previous suggested techniques.
Response:
Thank you so much for your kind words. We agree with your suggestions, and we tried to add quantitative results in our Conclusion section. However, when it comes to Abstract, it is really difficult to avoid abbreviations and to still have Methodology well described (as it is demanded by Journal etiquette). We did try to make it more concise and we truly hope you find it good enough for publication.
