Targeting the Cancer–Neuronal Crosstalk in the Pancreatic Cancer Microenvironment
Abstract
:1. Introduction
2. Clinical Relevance of Cancer–Neuronal Crosstalk
3. Effect of Cancer—Neuronal Crosstalk on PDAC-Associated Pain
4. Effect of Cancer–Neuronal Crosstalk on Cancer Growth and Invasiveness
Drug | Target | Current Status | Effect | Reference |
---|---|---|---|---|
Anti-NGF antibody or siRNA | NGF | Mouse model | Reduced neural outgrowth, reduced cancer growth, reduced metastasis | [54,55] |
Trk-Inhibitor | Trk (unselective) or trkA (selective) | Phase I–II | NA | NCT03556228, NCT05046847, NCT02097810, NCT02568267, NCT04879121 |
Plerixafor | CXCR4 antagonist | Phase I–II | NA | NCT03277209, NCT02179970, NCT04177810 |
miR-383 | ROBO3 | Mouse model | Reduced cancer growth and metastasis | [56] |
Minnelide | Several effects, including Inhibition des NF-κB | Phase I–II | NA | NCT03117920, NCT05557851, NCT03129139, NCT04896073 |
Propranolol | Beta adrenergic receptor | Phase II | NA | NCT03838029, NCT05451043 |
Celiac ganglion ablation | Denervation | Phase II–III | Reduction in cancer-associated pain, but no significant prolonged survival | [57] |
Splanchnicectomy | Denervation | Phase III | Reduction in cancer-associated pain, prolonged survival only in presence of cancer-associated pain before intervention | [58] |
Bethanechol | Muscarinic receptor M1 | Phase I–II | NA | NCT03572283, NCT05241249 |
5. Ablative Strategies in PDAC to Reduce Cancer-Associated Pain and Tumor Growth
6. Molecular Mechanisms of Cancer–Neuronal Crosstalk and Targeted Therapies
6.1. Neurons Are Attracted to PDAC Cells
6.2. PDAC Cells Are Attracted to Neurons
7. Conclusions and Future Directions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
References
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Capodanno, Y.; Hirth, M. Targeting the Cancer–Neuronal Crosstalk in the Pancreatic Cancer Microenvironment. Int. J. Mol. Sci. 2023, 24, 14989. https://doi.org/10.3390/ijms241914989
Capodanno Y, Hirth M. Targeting the Cancer–Neuronal Crosstalk in the Pancreatic Cancer Microenvironment. International Journal of Molecular Sciences. 2023; 24(19):14989. https://doi.org/10.3390/ijms241914989
Chicago/Turabian StyleCapodanno, Ylenia, and Michael Hirth. 2023. "Targeting the Cancer–Neuronal Crosstalk in the Pancreatic Cancer Microenvironment" International Journal of Molecular Sciences 24, no. 19: 14989. https://doi.org/10.3390/ijms241914989