Bacterial Cellulose-Based Blends and Composites: Versatile Biomaterials for Tissue Engineering Applications
, Emmanuel Asare, Syed Mohammad Daniel Syed Mohamed, Elliot N. Amadi and Ipsita Roy *Round 1
Reviewer 1 Report
The manuscript “Bacterial Cellulose based Blends and Composites; their uses in Tissue Engineering Applications” is a significant literature study with impact in applications of the tissue engineering.
Through this study, various researches are gathered, analyzed comparatively and, at the same time, certain limitations of some researches are presented, but also solutions for overcoming them.
Overall, this review is well-designed and organized, chronologically presenting the development of the applications of these materials in relation to the literature, which is current (the great majority after 2019). Also, the results research carried out in this field are well represented through the good quality of pictures.
I recommend revising the title.
Summarizing the positive aspects of this review, I consider that work is valuable, by bringing together research carried out in this domain, being an important informative material.
Author Response
Author’s response to the reviewer
The authors would like to thank all reviewers for taking the time to read and comment on this manuscript. Their comments were extremely helpful for the improvement of the manuscript. We hope that the revised manuscript fulfills their requirements. Please, find our responses below.
Reviewer comments:
Reviewer 1
The manuscript “Bacterial Cellulose based Blends and Composites; their uses in Tissue Engineering Applications”is a significant literature study with impact in applications of the tissue engineering.
Through this study, various researches are gathered, analyzed comparatively and, at the same time, certain limitations of some researches are presented, but also solutions for overcoming them.
Overall, this review is well-designed and organized, chronologically presenting the development of the applications of these materials in relation to the literature, which is current (the great majority after 2019). Also, the results research carried out in this field are well represented through the good quality of pictures. Summarizing the positive aspects of this review, I consider that work is valuable, by bringing together research carried out in this domain, being an important informative material
- I recommend revising the title.
Response: Authors agree with the reviewer’s comments. The title is now revised to:
“Bacterial Cellulose-based Blends and Composites: Versatile Biomaterials for Tissue Engineering Applications”
Reviewer 2 Report
The manuscript presents a review focused on bacterial cellulose (BC) applications within tissue engineering. The authors exhibited BC being one of the most versatile biomaterial with a huge potential in tissue engineering due to its favourable properties. The manuscript can be accepted after several issues are addressed:
- The authors research (papers) must be highlighted within the review.
- The 4.1 Section must be extended with other types of fillers/reinforcement (magnetite, clays, etc.)
- The 5.2.6 Section must be extended with literature scanning of wound dressing domain (wounds, burns, etc.)
- A new section focused on detailed BC characteristics (crystallinity, solubility behavior, biocompatibility, ability to interact/form blends with other polymers, biodegradability process in vivo/in vitro for scaffolds ) should be added. This approach would be very heplfull for researchers who start new directions which imply BC-related materials.
Author Response
Author’s response to the reviewer
The authors would like to thank all reviewers for taking their time to read and comment on this manuscript. Their comments were extremely helpful for the improvement of the manuscript. We hope that the revised manuscript fulfills their requirements. Please, find our responses below.
Reviewer comments:
Reviewer 2
The manuscript presents a review focused on bacterial cellulose (BC) applications within tissue engineering. The authors exhibited BC being one of the most versatile biomaterial with a huge potential in tissue engineering due to its favourable properties. The manuscript can be accepted after several issues are addressed:
- The authors research (papers) must be highlighted within the review.
Response: The authors appreciate reviewer’s suggestions. The research papers from our lab have now been incorporated in the revised manuscript.
(Page no. 18; line 694-698), (Page no. 21; Line 840-844) and (Page no. 27; Line 1078-1085)
- The 4.1 Section must be extended with other types of fillers/reinforcement (magnetite, clays, etc.)
Response: Section 4.1 has now been extended as suggested by the reviewer. A separate subsection as a subheading “4.1.3 BC modification using nanofillers” has now been added to the revised manuscript (Page no. 12-14; line 463-544).
- The 5.2.6 Section must be extended with literature scanning of wound dressing domain (wounds, burns, etc.)
Response: Section 5.2.6 has now been extended and the wound dressing application section has been incorporated (Page no. 26-27; line 1043-1085).
- A new section focused on detailed BC characteristics (crystallinity, solubility behavior, biocompatibility, ability to interact/form blends with other polymers, biodegradability process in vivo/in vitrofor scaffolds) should be added. This approach would be very helpful for researchers who start new directions which imply BC-related materials.
Response: The “section 2. Biosynthesis, Structure and Characteristics of BC” has been extended as suggested by the reviewer (Page no. 5-8; line 150-270). The authors also wish to clarify that the section on “interact/form blends with other polymers” is not included in this section since this has been discussed throughout the manuscript (e.g. Page no. 10 line 371 – 381, and Page no. 11; line 416-426)
The section entitled 2. Biosynthesis, Structure and Characteristics of BC has been divided into the following subheadings: (Page no. 3-8; line 87-270)
2.1. Biosynthesis
2.2. Structure
2.3 Crystallinity
2.3 Solubility
2.4 Biodegradability
2.5 Biocompatibility
Round 2
Reviewer 2 Report
Dear authors,
The manuscript can be accepted in the revised form.
