The Preventive Effects of Salubrinal against Pyrethroid-Induced Disruption of Adult Hippocampal Neurogenesis in Mice
Abstract
:1. Introduction
2. Results
2.1. Salubrinal Administration Effectively Prevents the Activation of the ER Stress in the Hippocampus of Adult Mice Induced by Exposure to Deltamethrin
2.2. Caspase-12 KO Mice Are Protected from Deltamethrin-Induced ER Stress
2.3. Inhibition of ER Stress with Salubrinal Attenuates Deltamethrin-Induced Reduction of Hippocampal Neurogenesis in Adult Mice
2.4. Caspase-12 KO Mice Are Protected from Deltamethrin-Induced Reduction of Hippocampal Neurogenesis in Adult Mice
2.5. Salubrinal Treatment Attenuates the Expression of CHOP in Hippocampal NPCs in Deltamethrin-Treated Mice
2.6. Salubrinal Attenuates the Expression of Caspase-12 in Hippocampal NPCs in Deltamethrin-Treated Mice
2.7. Caspase-12 Knockout Mice Are Protected against Deltamethrin-Induced Induction of ER Stress in Hippocampal NPCs
3. Discussion
4. Methods
4.1. Chemicals
4.2. Animals
4.3. Treatment
4.4. BrdU Administration and Tissue Preparation
4.5. Western Immunoblotting
4.6. Immunofluorescence
4.7. Statistical Analysis
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Toltin, A.C.; Belkadi, A.; Gamba, L.M.; Hossain, M.M. The Preventive Effects of Salubrinal against Pyrethroid-Induced Disruption of Adult Hippocampal Neurogenesis in Mice. Int. J. Mol. Sci. 2023, 24, 15614. https://doi.org/10.3390/ijms242115614
Toltin AC, Belkadi A, Gamba LM, Hossain MM. The Preventive Effects of Salubrinal against Pyrethroid-Induced Disruption of Adult Hippocampal Neurogenesis in Mice. International Journal of Molecular Sciences. 2023; 24(21):15614. https://doi.org/10.3390/ijms242115614
Chicago/Turabian StyleToltin, Abigail C., Abdelmadjid Belkadi, Laura M. Gamba, and Muhammad M. Hossain. 2023. "The Preventive Effects of Salubrinal against Pyrethroid-Induced Disruption of Adult Hippocampal Neurogenesis in Mice" International Journal of Molecular Sciences 24, no. 21: 15614. https://doi.org/10.3390/ijms242115614