Regulatory Roles of Histone Deacetylation in Metabolic Stress-Induced Expression of Caspase Recruitment Domain-Containing Protein 9 (CARD9) in Pancreatic β-Cells
Abstract
:1. Introduction
2. Results
2.1. TSA and SAHA Inhibit Metabolic Stress-Induced CARD9 Expression in INS-1 832/13 Cells
2.2. Hyperglycemic Conditions Significantly Increase the Expression of PKCδ in an HDAC-Independent Manner
3. Discussion
4. Materials and Methods
4.1. Materials
4.2. Culture of Insulin-Secreting INS-1 832/13 Cells
4.3. Western Blotting
4.4. Statistical Analysis
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Hali, M.; Pinto, N.; Gleason, N.; Kowluru, A. Regulatory Roles of Histone Deacetylation in Metabolic Stress-Induced Expression of Caspase Recruitment Domain-Containing Protein 9 (CARD9) in Pancreatic β-Cells. Int. J. Mol. Sci. 2023, 24, 15994. https://doi.org/10.3390/ijms242115994
Hali M, Pinto N, Gleason N, Kowluru A. Regulatory Roles of Histone Deacetylation in Metabolic Stress-Induced Expression of Caspase Recruitment Domain-Containing Protein 9 (CARD9) in Pancreatic β-Cells. International Journal of Molecular Sciences. 2023; 24(21):15994. https://doi.org/10.3390/ijms242115994
Chicago/Turabian StyleHali, Mirabela, Nelson Pinto, Noah Gleason, and Anjaneyulu Kowluru. 2023. "Regulatory Roles of Histone Deacetylation in Metabolic Stress-Induced Expression of Caspase Recruitment Domain-Containing Protein 9 (CARD9) in Pancreatic β-Cells" International Journal of Molecular Sciences 24, no. 21: 15994. https://doi.org/10.3390/ijms242115994