Emerging Role of Circular RNAs in Hepatocellular Carcinoma Immunotherapy
Abstract
:1. Introduction
2. Circular RNAs (CircRNAs)
2.1. What Are CircRNAs?
2.2. Biogenesis of CircRNAs
2.2.1. Intron Pairing-Driven Circularization
2.2.2. RBP-Induced Circularization
2.2.3. Lariat-Induced Circularization Driven by Spliceosomes
2.2.4. Self-Circularization of Introns
2.3. Functional Roles of CircRNAs
2.3.1. miRNA Sponge
2.3.2. Protein Sponge or Decoy
2.3.3. Protein Scaffolding
2.3.4. Transcriptional Regulation
2.3.5. Translation to Proteins and Peptides
2.3.6. Regulation of Epigenetic Alterations
2.4. Involvement of circRNAs in HCC Tumor Development and Progression
3. Immunotherapy
3.1. HCC Immunotherapy
3.2. CircRNAs in HCC Immunotherapy
4. Conclusions and Future Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Circular RNA | Class | Molecular Targets | In Vitro/In Vivo/Ex Vivo Model | References |
---|---|---|---|---|
SCD-circRNA2 | Oncogenic | MAPK1, RBM3 | Huh7 HepG2 HCT-15 NCI-N87 | [121] |
circRHOT1 | Oncogenic | NR2F6 | HCC Tissues | [122] |
circ-100338 | Oncogenic | MMP2, MMP9 | Hep3B HLE Huh7 BEL7402 SMCC7721 MHCC97L MHCC97H HCCLM3 HCCLM6 | [123] |
circ-0000092 | Oncogenic | miR-338-3p | Hep3B LM3 MHCC97L SK-hep1 HepG2 | [116] |
circPRMT5 | Oncogenic | miR-188-5p/HK2 axis | HCC tissues HCCLM3 SNU-387 | [124] |
circMAT2B | Oncogenic | PKM2 | HepG2 Huh7 SMMC-772 MHCC-97L MHCC-97H | [125] |
circASAP1 | Oncogenic | MAPK1 | MHCC97L MHCC97H HCCLM3 | [126] |
circβ-catenin | Oncogenic | β-catenin | Huh7 | [97] |
circUHRF1 | Oncogenic | UHRF1 | HepG2 HCCLM3 SMMC-7721 Huh 7 PLC/PRF/5 Hep3B | [127] |
circ-CDYL | Oncogenic | PI3K-AKT-MTORC1/β-catenin and NOTCH2 | HCCLM SMMC7721 | [128,129] |
circ-0046600 | Oncogenic | HIF-1α | HepG2 SK-HEP-1 | [130] |
hsa_circ_0101432 | Oncogenic | MAPK1 | Huh-7 SK-HEP-1 HepG2 HLE | [131] |
circMAN2B2 | Oncogenic | MAPK1 | HL-7702 | [132] |
circPTGR1 | Oncogenic | MET | HepG2 97L LM3 | [133] |
circ-DB | Oncogenic | miR-34a, and USP7 | HepG2 Hepa 1-6 3T3L1 | [134] |
circRNA Cdr1as | Oncogenic | AFP | SMMC-7721 Bel-7402 HepG2 Hep3B Huh-7 HB611 | [135] |
circRNA PVT1 | Oncogenic | miR-203/HOXD3 pathway | SMMC-7721 Huh-7 | [136] |
circPVT1 | Oncogenic | TRIM23/miR-377 axis | SNU-387 Huh-7 | [137] |
hsa_circ_0008450 | Oncogenic | EZH2 | SMMC7721 Sk-Hep-1 HepG2 Huh-7 HCCLM3 | [138] |
circ_0008450 | Oncogenic | miR-548 | HepG2 Huh-7, SMMC7721 Sk-Hep-1 HCCLM3 | [109] |
hsa_circRNA_103809 | Oncogenic | miR-377-3p/FGFR1/MAPK1 axis | MHCC97L Huh7 SK-HEP-1 Hep3B HCCLM3 | [139] |
circRNA-104718 | Oncogenic | miR-218-5p/TXNDC5 | HCC nude mice model | [110] |
circMYLK | Oncogenic | miR-362-3p/Rab23 | Huh7 Hep3B | [140] |
circ-ZNF652 | Oncogenic | miR-29a-3p/GUCD1 Axis | SNU-387 Huh-7 | [141] |
circ_0000267 | Oncogenic | miR-646 | HepG2 Huh-7 SMMC7721 Sk-Hep-1 HCCLM3 | [142] |
circ-FOXP1 | Oncogenic | miR-875-3p, miR-421, SOX9 factor | SNU-387 HepG2 Hep3B Huh7 SMMC-7721 HCCLM3 | [143] |
circRNA_104075 | Oncogenic | YAP-dependent tumorigenesis through regulating HNF4a | Bel-7402 SMMC-7721 Huh7 HepG2 Hep1 Bel-7404 THLE-3 HL-7702 | [144] |
hsa_circ_101280 | Oncogenic | miR-375/JAK2 | HepG2 SNU-398 | [145] |
circRNA-101368 | Oncogenic | HMGB1/RAGE | HCCLM3 HepG2 | [146] |
circ-ZEB1.33 | Oncogenic | miR-200a-3p-CDK6 | 97H Huh7 HepG2 SNU423 SNU475 L02 | [112] |
circFBLIM1 | Oncogenic | miR-346 | HCC tissues HCC mouse model | [147] |
hsa_circ_0103809 | Oncogenic | miR-490-5p/SOX2 signaling pathway | MHCC97H HepG2 Huh7 SMMC7721 SK-Hep1 | [148] |
hsa_circ_0016788 | Oncogenic | miR-486/CDK4 | HepG2 Hep3B Huh7 HCCLM3 MHCC97L | [113] |
hsa_circRBM23 | Oncogenic | miR-138 | HCC tissues HepG2 Huh7 Bel-7402 | [149] |
hsa_circ_0005075 | Oncogenic | miR-431 | SMMC-7721 | [150] |
circABCC2 | Oncogenic | miR-665 | HepG2 Bel-7402 MHCC97H | [151] |
hsa_circ_100338 | Oncogenic | MTOR signaling pathway | SMMC7721 Bel-7402 Hep3B | [152] |
circ_0091581 | Oncogenic | miR-591/FOSL2 axis | THLE-2 | [153] |
circPCNX | Oncogenic | miR-506 | HL-7702 SMMC-7721 HuH-7 Hep3B HepG2 | [154] |
hsa_circ_0056836 | Oncogenic | miR-766-3p/FOSL2 axis | Huh7 HepG2 SNU449 SK-HEP-1 | [155] |
circ- HOMER1 | Oncogenic | miR-1322 on CXCL6 | Sk-Hep-1 SMMC7721 HCCLM3 Huh-7 HepG2 | [156] |
circ_0091579 | Oncogenic | miR-136-5p/TRIM27 miR-1270/YAP1 miR-1225/PLCB1 | HCCLM3 MHCC97H Huh-7 | [157,158,159] |
circ_0001955 | Oncogenic | miR-516a-5p miR-646 miR-145-5p/NRAS | Huh-7 HepG2 SMMC-7721 Bel-7402 Hep-3B | [160,161,162] |
circTRIM33-12 | Tumor suppressor | miR-191 | HCC tissues MHCC97-L MHCC97-H LM3 | [163] |
circHIAT1 | Tumor suppressor | PTEN | Hep3B SMMC-7721 HepG2 LM3 | [164] |
circLARP4 | Tumor suppressor | miR-761/RUNX3/p53/CDKN1A pathway | Huh7 Hep3B SMMC7721 HepG2 | [165] |
circMTO1 | Tumor suppressor | miR-9-5p/NOX4 axis | HepG2 Hep3B | [166] |
circITCH | Tumor suppressor | miR-184 | Huh7 HCCLM3 SMMC-7721 MHCC97H HepG2 | [167] |
circFBXW4 | Tumor suppressor | miR-18b-3p/FBXW7 axis | LX-2 | [168] |
mmu_circ_34116 | Tumor suppressor | miR-661/PTPN11 | HepG2, SNU449 | [169] |
hsa_circ_0007874/cMTO1 | Tumor suppressor | miR-338-5p | HCCLM3 MHCC97-L Hep3B SMMC-7721 Huh7 Bel-7402 MHCC97-H | [170] |
circ608 | Tumor suppressor | miR-222/PINK1 | Primary hepatic stellate cells (PHSCs) from C57BL/6 mice | [171] |
hsa_circ_0070963 | Tumor suppressor | miR-223-3p LEMD3 | LX2 | [172] |
hsa_circ_0004018 | Tumor suppressor | miR-626/DKK3 | Huh7 Bel7402 SNU182 Hep3B SNU449 | [173] |
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Abaza, T.; El-Aziz, M.K.A.; Daniel, K.A.; Karousi, P.; Papatsirou, M.; Fahmy, S.A.; Hamdy, N.M.; Kontos, C.K.; Youness, R.A. Emerging Role of Circular RNAs in Hepatocellular Carcinoma Immunotherapy. Int. J. Mol. Sci. 2023, 24, 16484. https://doi.org/10.3390/ijms242216484
Abaza T, El-Aziz MKA, Daniel KA, Karousi P, Papatsirou M, Fahmy SA, Hamdy NM, Kontos CK, Youness RA. Emerging Role of Circular RNAs in Hepatocellular Carcinoma Immunotherapy. International Journal of Molecular Sciences. 2023; 24(22):16484. https://doi.org/10.3390/ijms242216484
Chicago/Turabian StyleAbaza, Tasneem, Mostafa K. Abd El-Aziz, Kerolos Ashraf Daniel, Paraskevi Karousi, Maria Papatsirou, Sherif Ashraf Fahmy, Nadia M. Hamdy, Christos K. Kontos, and Rana A. Youness. 2023. "Emerging Role of Circular RNAs in Hepatocellular Carcinoma Immunotherapy" International Journal of Molecular Sciences 24, no. 22: 16484. https://doi.org/10.3390/ijms242216484