Emerging Relevance of Ghrelin in Programmed Cell Death and Its Application in Diseases
Abstract
:1. Introduction
2. Ghrelin and Apoptosis
3. Ghrelin and Pyroptosis
4. Ghrelin and Autophagy
5. Ghrelin and Necroptosis
6. Discussion and Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Affected Cells | Diseases | Involved Pathways | Effects | Reference |
---|---|---|---|---|
Cardiomyocytes | Heart diseases caused by ERS | GHS-R1a/CaMKK/AMPK pathway | Inhibitory effects | [28] |
Heart diseases caused by H/R injury | Akt-mTOR signaling pathway | inhibitory effects | [29] | |
myocardial injury in sepsis | JAK/STAT signaling pathway | Inhibitory effects | [30] | |
myocardial infarction | Raf-MEK1/2-ERK1/2 signaling | Inhibitory effects | [31] | |
Neurons | Hypoxic-ischemic encephalopathy | GHSR-1α/AMPK/Sirt1/PGC-1α/UCP2 pathway | Inhibitory effects | [32] |
COH | Decreasing caspase3 | Inhibitory effects | [34] | |
diabetic encephalopathy | TLR4/NF-κB pathway | Inhibitory effects | [35] | |
human breast cancer cells | Breast cancer | PI3K/Akt/mTOR signaling pathway | Inhibitory effects | [36] |
human lens epithelial (HLE) cells | Diabetic cataract | Bcl-2 increases Bax decreases | Inhibitory effects | [37] |
pericytes | atherosclerosis | p38 MAPK-JNK pathway | Promoting effects | [38] |
cumulus cells | - | Unknown | Promoting effects | [39] |
MH7A synovial cells | - | cleaved-caspases-8, -9, and -3 increase | Promoting effects | [40] |
human adrenocortical cells, rat osteoblasts | - | Unknown | No effects | [41] |
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Zhang, X.; Zeng, Z.; Liu, Y.; Liu, D. Emerging Relevance of Ghrelin in Programmed Cell Death and Its Application in Diseases. Int. J. Mol. Sci. 2023, 24, 17254. https://doi.org/10.3390/ijms242417254
Zhang X, Zeng Z, Liu Y, Liu D. Emerging Relevance of Ghrelin in Programmed Cell Death and Its Application in Diseases. International Journal of Molecular Sciences. 2023; 24(24):17254. https://doi.org/10.3390/ijms242417254
Chicago/Turabian StyleZhang, Xue, Zihan Zeng, Yaning Liu, and Dan Liu. 2023. "Emerging Relevance of Ghrelin in Programmed Cell Death and Its Application in Diseases" International Journal of Molecular Sciences 24, no. 24: 17254. https://doi.org/10.3390/ijms242417254