Eosinophilic Chronic Rhinosinusitis and Pathogenic Role of Protease
Abstract
:1. Introduction
2. Eosinophilic Chronic Rhinosinusitis (eCRS)
2.1. Classification of Chronic Rhinosinusitis
2.2. Clinical Presentation, Diagnosis, and Treatment of eCRS
2.3. Pathogenesis of eCRS
3. Proteases
3.1. Definition and Functions of Protease
3.2. Classification of Proteases
3.3. Role of Proteases in Type 2 Inflammatory Diseases
3.4. Role of Protease Inhibitors in eCRS
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Class | Catalytic Residue | Examples | Functions |
---|---|---|---|
Serine Proteases | Serine | Trypsin Chymotrypsin Elastase Protein C | Digestion Blood clotting Immune response |
Cysteine Proteases | Cysteine | Papain Cathepsins Caspases | Senescence Apoptosis Immune response |
Aspartic Proteases | Aspartic acid | Pepsin Renin HIV-1 Protease | Digestion HIV maturation |
Metalloproteases | Zinc | Matrix metalloproteinases (MMPs) Aminopeptidase | Tissue remodeling Wound healing Cell signaling |
Threonine Proteases | Threonine | Proteasome enzymes | Intracellular protein degradation |
Glutamic Acid Proteases | Glutamic acid | Scytalidoglutamic peptidase Aspergilloglutamic peptidase | Mainly found in pathogenic fungi |
Asparagine Peptide Lyases | Asparagine | Viral capsid proteins Autotransporters of pathogenic bacteria | Mainly found in bacteria, virus |
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Kim, J.; Kwak, S.; Lee, J.; Park, I.-H.; Lee, S.H.; Shin, J.M.; Kim, T.H. Eosinophilic Chronic Rhinosinusitis and Pathogenic Role of Protease. Int. J. Mol. Sci. 2023, 24, 17372. https://doi.org/10.3390/ijms242417372
Kim J, Kwak S, Lee J, Park I-H, Lee SH, Shin JM, Kim TH. Eosinophilic Chronic Rhinosinusitis and Pathogenic Role of Protease. International Journal of Molecular Sciences. 2023; 24(24):17372. https://doi.org/10.3390/ijms242417372
Chicago/Turabian StyleKim, Jaehyeong, Sooun Kwak, Juhyun Lee, Il-Ho Park, Seung Hoon Lee, Jae Min Shin, and Tae Hoon Kim. 2023. "Eosinophilic Chronic Rhinosinusitis and Pathogenic Role of Protease" International Journal of Molecular Sciences 24, no. 24: 17372. https://doi.org/10.3390/ijms242417372