The Anti-Inflammatory Effect of Multi-Wavelength Light-Emitting Diode Irradiation Attenuates Dry Eye Symptoms in a Scopolamine-Induced Mouse Model of Dry Eye
Abstract
:1. Introduction
2. Results
2.1. Multi-Wavelength LED Irradiation Has No Toxicity on Human Corneal Epithelial Cells
2.2. Effect of Multi-Wavelength LED Irradiation on the Clinical Features of Scopolamine-Induced Dry Eye
2.3. Effect of Multi-Wavelength LED Irradiation on Corneal Epithelia
2.4. Effect of Multi-Wavelength LED Irradiation on Pro-Inflammatory Cytokine Levels
3. Discussion
4. Materials and Methods
4.1. LED Treatment
4.2. Cell Viability and Proliferation Assays
4.3. Mouse Model of Dry Eye and the Experimental Procedure
4.4. Tear Volume Test
4.5. Evaluation of Corneal Damage
4.6. Histology
4.7. Immunohistochemistry
4.8. Statistics
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Treatment Wavelength (nm) | 680 nm | 780 nm | 830 nm |
---|---|---|---|
Light type | Light-emitting diode | ||
Chip dimension | 1000 μm × 1000 μm | ||
Mode | Continuous wave (CW) | ||
FWHM | 22 nm | 25 nm | 35 nm |
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Goo, H.; Lee, Y.-J.; Lee, S.; Hong, N. The Anti-Inflammatory Effect of Multi-Wavelength Light-Emitting Diode Irradiation Attenuates Dry Eye Symptoms in a Scopolamine-Induced Mouse Model of Dry Eye. Int. J. Mol. Sci. 2023, 24, 17493. https://doi.org/10.3390/ijms242417493
Goo H, Lee Y-J, Lee S, Hong N. The Anti-Inflammatory Effect of Multi-Wavelength Light-Emitting Diode Irradiation Attenuates Dry Eye Symptoms in a Scopolamine-Induced Mouse Model of Dry Eye. International Journal of Molecular Sciences. 2023; 24(24):17493. https://doi.org/10.3390/ijms242417493
Chicago/Turabian StyleGoo, Hyeyoon, Yea-Jin Lee, Sangkeun Lee, and Namgue Hong. 2023. "The Anti-Inflammatory Effect of Multi-Wavelength Light-Emitting Diode Irradiation Attenuates Dry Eye Symptoms in a Scopolamine-Induced Mouse Model of Dry Eye" International Journal of Molecular Sciences 24, no. 24: 17493. https://doi.org/10.3390/ijms242417493