Insight into Drug Resistance in Status Epilepticus: Evidence from Animal Models

Wang, Fei; Zhang, Qingyang; Wang, Yu; Chen, Junzi; Wang, Yi

doi:10.3390/ijms24032039

Open AccessReview

Insight into Drug Resistance in Status Epilepticus: Evidence from Animal Models

by

Fei Wang

¹,

Qingyang Zhang

¹,

Yu Wang

¹,

Junzi Chen

¹ and

Yi Wang

^1,2,*

¹

Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China

²

Department of Neurology, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053, China

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2023, 24(3), 2039; https://doi.org/10.3390/ijms24032039

Submission received: 18 November 2022 / Revised: 11 January 2023 / Accepted: 15 January 2023 / Published: 20 January 2023

(This article belongs to the Special Issue Advances in Epilepsy and Antiepileptic Drugs 2.0)

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Abstract

Status epilepticus (SE), a condition with abnormally prolonged seizures, is a severe type of epilepsy. At present, SE is not well controlled by clinical treatments. Antiepileptic drugs (AEDs) are the main therapeutic approaches, but they are effective for SE only with a narrow intervening window, and they easily induce resistance. Thus, in this review, we provide an updated summary for an insight into drug-resistant SE, hoping to add to the understanding of the mechanism of refractory SE and the development of active compounds. Firstly, we briefly outline the limitations of current drug treatments for SE by summarizing the extensive experimental literature and clinical data through a search of the PubMed database, and then summarize the common animal models of refractory SE with their advantages and disadvantages. Notably, we also briefly review some of the hypotheses about drug resistance in SE that are well accepted in the field, and furthermore, put forward future perspectives for follow-up research on SE.

Keywords: status epilepticus; drug target; animal models; hypothesis

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MDPI and ACS Style

Wang, F.; Zhang, Q.; Wang, Y.; Chen, J.; Wang, Y. Insight into Drug Resistance in Status Epilepticus: Evidence from Animal Models. Int. J. Mol. Sci. 2023, 24, 2039. https://doi.org/10.3390/ijms24032039

AMA Style

Wang F, Zhang Q, Wang Y, Chen J, Wang Y. Insight into Drug Resistance in Status Epilepticus: Evidence from Animal Models. International Journal of Molecular Sciences. 2023; 24(3):2039. https://doi.org/10.3390/ijms24032039

Chicago/Turabian Style

Wang, Fei, Qingyang Zhang, Yu Wang, Junzi Chen, and Yi Wang. 2023. "Insight into Drug Resistance in Status Epilepticus: Evidence from Animal Models" International Journal of Molecular Sciences 24, no. 3: 2039. https://doi.org/10.3390/ijms24032039

APA Style

Wang, F., Zhang, Q., Wang, Y., Chen, J., & Wang, Y. (2023). Insight into Drug Resistance in Status Epilepticus: Evidence from Animal Models. International Journal of Molecular Sciences, 24(3), 2039. https://doi.org/10.3390/ijms24032039

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Insight into Drug Resistance in Status Epilepticus: Evidence from Animal Models

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