Origin of Retinal Oscillatory Potentials in the Mouse, a Tool to Specifically Locate Retinal Damage
Abstract
:1. Introduction
2. Results
2.1. The OP Components of the Control Response
Waveforms
2.2. The OPs in Mixed Rod/Cone-Driven Response under the Effect of Injected Agents
2.3. The OPs in Rod-Driven and Cone-Driven Response under the Effect of Injected Agents
3. Discussion
4. Materials and Methods
4.1. Animal Model, Legal Protection, and Maintenance
4.2. Animal Preparation and Intravitreal Drug Injection
4.3. Signal Recording and Light Stimulation
4.4. OP Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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APB | GABA | Bicuculline | TPMPA | Glutamate | DNQX | Glycine | Strychnine | HEPES | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(25 mM) | (100 mM) | (10 mM) | (25 mM) | (100 mM) | (30 mM) | (10 mM) | (25 mM) | (25 mM) | ||||||||||
LE | RE | LE | RE | LE | RE | LE | RE | LE | RE | LE | RE | LE | RE | LE | RE | LE | RE | |
mean | 4.10 | 0.00 | 4.67 | 0.00 | 4.26 | 2.30 | 4.10 | 4.03 | 4.06 | 0.00 | 3.90 | 0.00 | 3.94 | 1.88 | 4.50 | 2.00 | 4.28 | 1.63 |
SD | 0.28 | 0.00 | 0.88 | 0.00 | 0.33 | 0.61 | 0.28 | 0.21 | 0.33 | 0.00 | 0.28 | 0.00 | 0.17 | 0.45 | 0.85 | 1.05 | 0.57 | 1.12 |
n | 6 | 6 | 6 | 6 | 6 | 6 | 4 | 6 | 4 | |||||||||
p | <0.001 | <0.001 | <0.001 | 0.285 | <0.001 | <0.001 | 0.003 | <0.001 | 0.023 |
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Liao, F.; Liu, H.; Milla-Navarro, S.; Villa, P.d.l.; Germain, F. Origin of Retinal Oscillatory Potentials in the Mouse, a Tool to Specifically Locate Retinal Damage. Int. J. Mol. Sci. 2023, 24, 3126. https://doi.org/10.3390/ijms24043126
Liao F, Liu H, Milla-Navarro S, Villa Pdl, Germain F. Origin of Retinal Oscillatory Potentials in the Mouse, a Tool to Specifically Locate Retinal Damage. International Journal of Molecular Sciences. 2023; 24(4):3126. https://doi.org/10.3390/ijms24043126
Chicago/Turabian StyleLiao, Fei, Haitao Liu, Santiago Milla-Navarro, Pedro de la Villa, and Francisco Germain. 2023. "Origin of Retinal Oscillatory Potentials in the Mouse, a Tool to Specifically Locate Retinal Damage" International Journal of Molecular Sciences 24, no. 4: 3126. https://doi.org/10.3390/ijms24043126