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Review

Role of Damage-Associated Molecular Patterns (DAMPS) in the Postoperative Period after Colorectal Surgery

by
María José Caballero-Herrero
1,†,
Esther Jumilla
1,†,
Manuel Buitrago-Ruiz
2,
Graciela Valero-Navarro
2,3,*,‡ and
Santiago Cuevas
1,*,‡
1
Molecular Inflammation Group, Biomedical Research Institute of Murcia Pascual Parrilla (IMIB), 30120 Murcia, Spain
2
General and Digestive System Surgery, Morales Meseguer University Hospital, 30008 Murcia, Spain
3
Surgical Research in Health Area, Institute of Biosanitary Research Pascual Parrilla (IMIB), Department of Surgery, Pediatrics, Obstetrics and Gynecology, University of Murcia, 30100 Murcia, Spain
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work as co-first authors.
‡
These authors contributed equally to this work as co-senior authors.
Int. J. Mol. Sci. 2023, 24(4), 3862; https://doi.org/10.3390/ijms24043862
Submission received: 16 January 2023 / Revised: 6 February 2023 / Accepted: 11 February 2023 / Published: 15 February 2023
(This article belongs to the Special Issue Mechanisms of Innate Immune Activation and Regulation in Health and Disease (Volume 2))
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Abstract

Anastomotic leakage (AL) is a defect of the intestinal wall at the anastomotic site and is one of the most severe complications in colorectal surgery. Previous studies have shown that the immune system response plays a significant role in the development of AL. In recent years, DAMPs (damage-associated molecular patterns) have been identified as cellular compounds with the ability to activate the immune system. The NLRP3 inflammasome plays an important role in the inflammatory responses which are mediated by DAMPs such as ATP, HSP proteins or uric acid crystals, when found in extracellular environments. Recent publications suggest that systemic concentration of DAMPs in patients with colorectal surgery may determine the inflammatory process and have a role in the occurrence of AL and other post-surgery complications. This review provides valuable knowledge about the current evidence supporting this hypothesis and highlights the possible role of these compounds in postoperative processes, which could open a new path to explore new strategies to prevent possible post-surgical complications.
Keywords: damage-associated molecular patterns; anastomotic leak; NLRP3 inflammasome; colorectal surgery damage-associated molecular patterns; anastomotic leak; NLRP3 inflammasome; colorectal surgery

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MDPI and ACS Style

Caballero-Herrero, M.J.; Jumilla, E.; Buitrago-Ruiz, M.; Valero-Navarro, G.; Cuevas, S. Role of Damage-Associated Molecular Patterns (DAMPS) in the Postoperative Period after Colorectal Surgery. Int. J. Mol. Sci. 2023, 24, 3862. https://doi.org/10.3390/ijms24043862

AMA Style

Caballero-Herrero MJ, Jumilla E, Buitrago-Ruiz M, Valero-Navarro G, Cuevas S. Role of Damage-Associated Molecular Patterns (DAMPS) in the Postoperative Period after Colorectal Surgery. International Journal of Molecular Sciences. 2023; 24(4):3862. https://doi.org/10.3390/ijms24043862

Chicago/Turabian Style

Caballero-Herrero, María José, Esther Jumilla, Manuel Buitrago-Ruiz, Graciela Valero-Navarro, and Santiago Cuevas. 2023. "Role of Damage-Associated Molecular Patterns (DAMPS) in the Postoperative Period after Colorectal Surgery" International Journal of Molecular Sciences 24, no. 4: 3862. https://doi.org/10.3390/ijms24043862

APA Style

Caballero-Herrero, M. J., Jumilla, E., Buitrago-Ruiz, M., Valero-Navarro, G., & Cuevas, S. (2023). Role of Damage-Associated Molecular Patterns (DAMPS) in the Postoperative Period after Colorectal Surgery. International Journal of Molecular Sciences, 24(4), 3862. https://doi.org/10.3390/ijms24043862

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