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Article

Cross-Reactivity of Intraoral Allergic Contact Mucositis in the Nickel-Sensitized Ear Model of Metal Allergy

by
Ryota Matsubara
1,2,
Kenichi Kumagai
2,3,*,
Keisuke Nasu
2,4,
Takamasa Yoshizawa
2,4,
Kazutaka Kitaura
2,5,
Motoaki Suzuki
2,6,
Yoshiki Hamada
4 and
Ryuji Suzuki
2,5
1
Department of Oral and Maxillofacial Surgery, Sendai Tokushukai Hospital, Sendai 981-3116, Japan
2
Department of Rheumatology and Clinical Immunology, Clinical Research Center for Rheumatology and Allergy, Sagamihara National Hospital, National Hospital Organization, Sagamihara 252-0392, Japan
3
Department of Oral and Maxillofacial Surgery, Dentistry and Orthodontics, The University of Tokyo Hospital, Tokyo 113-8655, Japan
4
Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, Yokohama 230-8501, Japan
5
Repertoire Genesis Inc., Osaka 567-0085, Japan
6
Department of Anatomy and Physiology, Faculty of Medicine, Saga University, Saga 849-8501, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(4), 3965; https://doi.org/10.3390/ijms24043965
Submission received: 31 December 2022 / Revised: 4 February 2023 / Accepted: 12 February 2023 / Published: 16 February 2023
(This article belongs to the Special Issue Oral Medicine and Immunity)
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Abstract

Cross-reactivity of metal allergies can make metal allergy treatment complicated because the background of immune response in cross-reactions remains unknown. In clinical settings, cross-reactivity among several metals has been suspected. However, the precise mechanism of immune response in cross-reactivity is unclear. Two sensitizations with nickel, palladium, and chromium plus lipopolysaccharide solution into the postauricular skin were followed by a single nickel, palladium, and chromium challenge of the oral mucosa to generate the intraoral metal contact allergy mouse model. Results showed that the infiltrating T cells in nickel-sensitized, palladium- or chromium-challenged mice expressed CD8+ cells, cytotoxic granules, and inflammation-related cytokines. Thus, nickel ear sensitization can cause cross-reactive intraoral metal allergy.
Keywords: metal allergy; nickel; palladium; chromium; cross-reactivity; allergic contact mucositis; metal-specific T cells metal allergy; nickel; palladium; chromium; cross-reactivity; allergic contact mucositis; metal-specific T cells

Share and Cite

MDPI and ACS Style

Matsubara, R.; Kumagai, K.; Nasu, K.; Yoshizawa, T.; Kitaura, K.; Suzuki, M.; Hamada, Y.; Suzuki, R. Cross-Reactivity of Intraoral Allergic Contact Mucositis in the Nickel-Sensitized Ear Model of Metal Allergy. Int. J. Mol. Sci. 2023, 24, 3965. https://doi.org/10.3390/ijms24043965

AMA Style

Matsubara R, Kumagai K, Nasu K, Yoshizawa T, Kitaura K, Suzuki M, Hamada Y, Suzuki R. Cross-Reactivity of Intraoral Allergic Contact Mucositis in the Nickel-Sensitized Ear Model of Metal Allergy. International Journal of Molecular Sciences. 2023; 24(4):3965. https://doi.org/10.3390/ijms24043965

Chicago/Turabian Style

Matsubara, Ryota, Kenichi Kumagai, Keisuke Nasu, Takamasa Yoshizawa, Kazutaka Kitaura, Motoaki Suzuki, Yoshiki Hamada, and Ryuji Suzuki. 2023. "Cross-Reactivity of Intraoral Allergic Contact Mucositis in the Nickel-Sensitized Ear Model of Metal Allergy" International Journal of Molecular Sciences 24, no. 4: 3965. https://doi.org/10.3390/ijms24043965

APA Style

Matsubara, R., Kumagai, K., Nasu, K., Yoshizawa, T., Kitaura, K., Suzuki, M., Hamada, Y., & Suzuki, R. (2023). Cross-Reactivity of Intraoral Allergic Contact Mucositis in the Nickel-Sensitized Ear Model of Metal Allergy. International Journal of Molecular Sciences, 24(4), 3965. https://doi.org/10.3390/ijms24043965

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