An Overview towards Zebrafish Larvae as a Model for Ocular Diseases
Abstract
:1. Introduction
2. Zebrafish Ocular Development and Physiology
3. Zebrafish as a Model for Ocular Pathologies
3.1. Cataract
3.2. Glaucoma
3.3. Age-Related Macular Degeneration (AMD)
3.4. Diabetic Retinopathy (DR)
3.5. Retinitis Pigmentosa (RP)
4. Ocular Infections
5. Zebrafish Larvae as a Model for Retina Regeneration
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Ocular Disease | Reference | Model | Zebrafish Features * | Human Features * |
---|---|---|---|---|
Cataracts (congenital or age-related) | Morris, 2011 [30] | Extensive review | ||
Li et al., 2012 [31] | Mutation of crygc | Embrionic lens defects | Congenital cataract phenotype | |
Wu, Zou, Mishr & Mchaourab, 2018 [32] | Mutation of cryga and crygb | |||
Mishra et al., 2018 [33] | Mutation of crygb | |||
Vorontsova, Gehring, Hall, & Schilling, 2018 [34] | Mutation of aqp0a and aqp0b | |||
Zhang et al., 2020 [35] | dnase1l1l knockout | Lens denucleation defect and cataract | Not described | |
Anophthalmia (A) | Yin et al., 2014 [19] | Mutation of rx3 | Anophthalmia and expanded forebrain | Microphthalmia and anophthalmia |
Synophthlamia/cyclopia | Santos-Ledo et al., 2013 [20] | six3a, rx3 and rx1 disruption | Cyclopia | Holoprosencephaly and cyclopia |
Swartz et al., 2013 [36] | vangl2, plk1, hinfp, mars, and foxi1 disruption | Synophthalmia and narrowing of the palatal skeleton | Not described | |
Coloboma (C) | Pillai-Kastoori et al., 2014 [21] | Mutation of sox11 | Delayed and abnormal lens formation, coloboma, and reduction in rod photoreceptors | Coloboma phenotype |
Weaver, Piedade, Meshram, & Famulski, 2018 [22] | pax2a depletion | Optic fissure (OP) failure | Not described | |
Ouyang et al., 2022 [37] | Loss-of-funtion of hnrnph1 | Coloboma | High myopia | |
Corneal opacities | Reis et al., 2019 [38] | Mutation of wdr37 | Cataract, microphthalmia, glaucoma, corneal clouding | Corneal opacity, coloboma, microcornea |
Iris hypoplasia | Chawla, Swain, Williams, & Bohnsack, 2018 [23] | Increase/decrease in retinoic acid modulating myoc and pitx2 | Changes in the ventral iridocorneal angle and decreased aqueous outflow | Corneal, iris, and trabecular meshwork abnormalities |
Aniridia | Seese et al., 2021 [24] | Loss-of-function of mab21l1 | Congenital glaucoma aphakia, malformed retina, and abnormally thick cornea, severe microphthalmia, disorganized retinal lamination, abnormal anterior structures | Microphthalmia, variable aniridia, coloboma, microcornea, lens defects (microspherophakia, cataracts) and nystagmus |
Peter’s anomaly | Shi et al., 2005 [25] | Mutation of pitx3 | Lens or other anterior segment defects | Anterior segment dysgenesis, Peter’s anomaly, and cataracts. |
Axenfeld–Rieger syndrome | Reviewed by French, 2021 [39] | Extensive review | ||
Microphthalmia (M) | Casey et al., 2011 [40] | Mutation of stra6 | Congenital eye malformations | Non-syndromic anophthalmia |
Aphakia | Gath & Gross, 2019 [26] | Loss-of-function of mab21l2 | Lens and retina defects, coloboma | Defects of lens development |
Corneal dystrophies | Oliver et al., 2015 [41] | Mutation of col17a1a | Not described | Epithelial recurrent erosion dystrophy (ERED) |
Human congenital nystagmus (HCN)/infantile nystagmus syndrome (INS) | Huang et al., 2006 [27] | Defective retinotectal projections | Strong spontaneous eye oscillations | Congenital nystagmus |
Maurer, Huang, & Neuhauss, 2011 [28] | ||||
Huber-Reggi et al., 2011 [29] |
Ocular Disease | Reference | Model | Zebrafish Features * | Human Features * |
---|---|---|---|---|
Age-related macular degeneration (AMD) | Noel et al., 2020 [49] | Mutation of rp1l1 | Photoreceptor degeneration | Photoreceptor diseases |
Rastoin, Pagès, & Dufies, 2020 [50] | Extensive review | |||
Xia et al., 2020 [51] | Knockdown of ube3d | Neovascular AMD | Oxidative damage in retinal pigment epithelium (hRPE) (in vitro) | |
Cheng et al., 2021 [52] | Blue light-induced retinal damage | Retinal degeneration | Not described | |
Noel, Allison, MacDonald, & Hocking, 2022 [53] | Extensive review | |||
Diabetic retinopathy | Jung, Kim, Lee, & Kim, 2016 [54] | Glucose exposure | Neovascularization, dilation of hyaloid-retinal vessels | Diabetic retinopathy |
Lee & Yang, 2021 [55] | ||||
Singh et al., 2019 [56] | Neovascularization, dilation of hyaloid-retinal vessels, and microvascular alterations | |||
Reichenbach et al., 2007 [57] | Extensive review | |||
Li et al., 2019 [58] | Methylglyoxal exposure | Neovascularization, dilation of hyaloid-retinal vessels | Diabetic retinopathy | |
Glaucoma | Skarie & Link, 2009 [59] | Knockdown of foxc1 | Disruption of vascular endothelial tissue | Glaucoma |
Iglesias et al., 2014 [60] | Knockdown of six6b | Small eye phenotype | Not described | |
Williams, Eason, Chawla, & Bohnsack, 2017 [61] | Manipulation of cyp1b1 | Regulation of ocular fissure closure | Mutation on cyp1b1 is related to primary infantile-onset glaucoma | |
Giannaccini et al., 2018 [62] | Exposure to H2O2 | Oxidative stress-induced damage | Not described | |
Cavodeassi & Wilson, 2019 [18] | Extensive review | |||
Morales-Cámara et al., 2020 [63] | Knockout of guca1c | Retinal ganglion cell apoptosis | Not described | |
Retinitis pigmentosa (RP) | Zelinka, Sotolongo-Lopez, & Fadool, 2018 [64] | Mutations of rh1–1 | Rod degeneration | Autosomal dominant retinitis pigmentosa |
Ganzen et al., 2021 [65] | rho:NTR zebrafish line | Rod ablation | Not described | |
Santhanam et al., 2020 [66] | Mutation of p23h | Rod degeneration | Not described | |
Campochiaro & Mir, 2018 [67] | Extensive review | |||
Crouzier et al., 2021 [68] | Mutation of pde6a | Photoreceptor degeneration | Retinitis pigmentosa | |
Kawase et al., 2016 [69] | Ligh-induced retinopathy | Not described | ||
Lu et al., 2019 [70] | Mutation of prom1 | Retinitis pigmentosa, macular degeneration, and cone–rod dystrophy | ||
Noel et al., 2020 [49] | Mutation of rp1l1 | Photorecepetor disease | ||
Schlegel, Ramkumar, von Lintig, & Neuhauss, 2021 [42] | Mutation of rlbp1 | |||
Zhang et al., 2021 [71] | rho:NTR zebrafish line | Rod ablation | Not described | |
Achromatopsia | Kennedy et al., 2007 [72] | No optokinetic response of mutant (nof) | Achromatopic blindness | Not described |
Stearns, Evangelista, Fadool, & Brockerhoff, 2007 [73] | Mutation of pde6c | Blindness (degeneration of cone photoreceptors) | Achromatopsia | |
Viringipurampeer et al., 2014 [74] | ||||
Huang et al., 2018 [75] | Mutation of per2 | Reduced vision behavior | Not described | |
Cone–rod dystrophy | Iribarne et al., 2017 [76] | Zebrafish Gold Rush mutant (aipl1 mutant) | Cone-specific degeneration | Leber congenital amaurosis 4 (LCA4) |
Daly et al., 2017 [77] | Zebrafish dying on edge (dye) mutant | Defective visual behavior, altered retina morphology, photoreceptor degeneration | Visual impairment | |
Schlegel et al., 2019 [78] | Knockout of cacna2d4b | Electroretinogram impaired response (defective phototransduction) | Retinal dysfunction (impaired cone vision) | |
Nadolski et al., 2020 [43] | Mutation of gdf6a | Microphthalmia, photoreceptor degeneration | Not described | |
Congenital stationary night blindness | Bahadori et al., 2006 [46] | Zebrafish fade out (fad) mutant | Retina structural defects, photoreceptor degeneration | Hermansky–Pudlak syndrome (HPS) |
Jia et al., 2014 [44] | Zebrafish wait until dark (wud) mutant | Electroretinogram impaired response (defective phototransduction) | Congenital stationary night blindness type 2 (CSNB2) | |
Leber’s congenital amaurosis (LCA) | Stiebel-Kalish et al., 2012 [48] | Knockdown of gucy2df | Shortening of cone and rod outer segments. | Leber congenital amaurosis-1 (LCA1). |
Minegishi, Nakaya, & Tomarev, 2018 [47] | Mutation of cct2 | Microphthalmia | ||
Bardet–Biedl syndrome (BBS) | Castro-Sánchez et al., 2019 [79] | Mutation of bbs | Microphthalmia | Ciliopathy |
Song et al., 2020 [80] | Photoreceptor degeneration | |||
Usher syndrome | Gopal et al., 2015 [81] | Knockout of clrn1 | Ciliopathy | Ciliopathy |
Miles, Blair, Emili, & Tropepe, 2021 [82] | Mutation of pcdh15b | Loss of photoreceptor integrity | Blindness associated with Usher syndrome type 1 (USH1) | |
Joubert syndrome | Song & Perkins, 2018 [83] | Mutation of arl13a | Slow progressive photoreceptor degeneration | Joubert syndrome phenotype |
Liu, Cao, Yu, & Hu, 2020 [84] | Knockout of tmem216 | Photoreceptor degeneration | ||
Rusterholz, Hofmann, & Bachmann-Gagescu, 2022 [85] | Extensive review | |||
Meckel-Gruber syndrome | Lessieur et al., 2019 [86] | Zebrafish cep290fh297/fh297 mutant | Slow progressive photoreceptor degeneration | Meckel-Gruber syndrome phenotype |
Hermansky-Pudlak syndrome | Bahadori et al., 2006 [46] | Zebrafish fade out (fad) mutant | Retina structural defects, photoreceptor degeneration | Hermansky–Pudlak syndrome (HPS) |
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Rosa, J.G.S.; Lopes-Ferreira, M.; Lima, C. An Overview towards Zebrafish Larvae as a Model for Ocular Diseases. Int. J. Mol. Sci. 2023, 24, 5387. https://doi.org/10.3390/ijms24065387
Rosa JGS, Lopes-Ferreira M, Lima C. An Overview towards Zebrafish Larvae as a Model for Ocular Diseases. International Journal of Molecular Sciences. 2023; 24(6):5387. https://doi.org/10.3390/ijms24065387
Chicago/Turabian StyleRosa, João Gabriel Santos, Monica Lopes-Ferreira, and Carla Lima. 2023. "An Overview towards Zebrafish Larvae as a Model for Ocular Diseases" International Journal of Molecular Sciences 24, no. 6: 5387. https://doi.org/10.3390/ijms24065387