Neutrophil Extracellular Traps and Cancer: Trapping Our Attention with Their Involvement in Ovarian Cancer
Abstract
:1. Introduction
2. New Roles for Neutrophils
2.1. NETosis: A New Mechanism of Neutrophil Defense
2.2. Mechanism of NETosis Formation
2.3. NETosis and Thrombosis
3. Neutrophils in Cancer
3.1. Tumor Associated Neutrophils (TANs)
3.2. Pro-Tumor Role of Neutrophils in Cancer
Role of TLRs in Cancer
3.3. Pro-Tumor strategies Involving NETs
3.4. Anti-Tumor Role of Neutrophils in Cancer
3.5. Anti-Tumor Strategies Involving NETs
4. NETs in Ovarian Cancer
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Authors [Refs.] | Year | Title | Experimental Design | Study Cohort/Sample | NETs Markers Measured | Type |
---|---|---|---|---|---|---|
Lee, et al. [109] | 2019 | Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum. | In vivo: Orthotopic tumors in immunocompetent C57BL/6 mice, analysis ovarian cancer cell implantation kinetics into omentum, neutrophil levels. In vitro: Stimulation of neutrophils with OC cells conditioned media, analysis of mice and human omental tissues. | n = 46 C57BL/6 mice n = 5 NSG mice n = 5 Nude mice n = 10 Omentum from patients without cancer n = 10 Omentum from patients with SLMP n = 10 Omentum from patients with HGSOC | DNA, citH3 | Original Research |
Singel, et al. [129] | 2018 | Mitochondrial DNA in the tumor microenvironment activates neutrophils and is associated with worse outcomes in patients with advanced epithelial ovarian cancer. | In vitro: NETs markers analysis in ascites samples from patients with advanced EOC, stimulation of healthy donor neutrophils and platelets. | n = 68 Ascites from patients with advanced EOC n = 5 Resected tumors from patients with advanced EOC | mtDNA, NE | Original Research |
Muqaku, et al. [130] | 2020 | Neutrophil Extracellular Trap Formation Correlates with Favorable Overall Survival in High Grade Ovarian Cancer. | In vitro: Multi-omics and fluorescence-activated cell sorting data from ascites samples of HGSOC patients. | n = 18 Melanoma patients n = 25 HGSOC patients n = 36 HGSOC patients data from other papers | NE, MPO, calrpotectin | Original Research |
Dobilas, et al. [131] | 2022 | Circulating markers of neutrophil extracellular traps (NETs) in patients with ovarian tumors. | In vitro: NETs markers analysis in plasma samples from patients with ovarian tumors. | n = 199 Patients admitted for primary surgery of adnexal masses | ds-DNA, citH3 | Original Research |
Tomás-Pérez, et al. [132] | 2023 | Increased levels of NETosis biomarkers in high-grade serous ovarian cancer patients’ biofluids: potential role in disease diagnosis and management. | In vitro: NETs markers analysis in plasma samples and ascites from women with advanced HGSOC and control women. | n = 45 Plasma and PF samples from HGSOC patients n = 40 Plasma and PF samples from control women | cfDNA, nucleosomes, citH3, calprotectin, MPO | Original Research |
Tamura, et al. [133] | 2022 | Neutrophil extracellular traps (NETs) reduce the diffusion of doxorubicin which may attenuate its ability to induce apoptosis of ovarian cancer cells. | In vitro and ex vivo: Analysis of the effect of NETs on anti-cancer drugs pharmacokinetics. | n = N/A Blood samples from healthy patients n = N/A balb/c nude mice | N/A | Original Research |
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Castaño, M.; Tomás-Pérez, S.; González-Cantó, E.; Aghababyan, C.; Mascarós-Martínez, A.; Santonja, N.; Herreros-Pomares, A.; Oto, J.; Medina, P.; Götte, M.; et al. Neutrophil Extracellular Traps and Cancer: Trapping Our Attention with Their Involvement in Ovarian Cancer. Int. J. Mol. Sci. 2023, 24, 5995. https://doi.org/10.3390/ijms24065995
Castaño M, Tomás-Pérez S, González-Cantó E, Aghababyan C, Mascarós-Martínez A, Santonja N, Herreros-Pomares A, Oto J, Medina P, Götte M, et al. Neutrophil Extracellular Traps and Cancer: Trapping Our Attention with Their Involvement in Ovarian Cancer. International Journal of Molecular Sciences. 2023; 24(6):5995. https://doi.org/10.3390/ijms24065995
Chicago/Turabian StyleCastaño, María, Sarai Tomás-Pérez, Eva González-Cantó, Cristina Aghababyan, Andrea Mascarós-Martínez, Nuria Santonja, Alejandro Herreros-Pomares, Julia Oto, Pilar Medina, Martin Götte, and et al. 2023. "Neutrophil Extracellular Traps and Cancer: Trapping Our Attention with Their Involvement in Ovarian Cancer" International Journal of Molecular Sciences 24, no. 6: 5995. https://doi.org/10.3390/ijms24065995