Inhibitory Effects of Thermolysis Transformation Products of Rotenone on Nitric Oxide Production
, Hanui Lee 1,2,†, Seung Sik Lee 1,3, Byung Yeoup Chung 1, Hyoung-Woo Bai 1,2,3,* and Tae Hoon Kim 4,*Round 1
Reviewer 1 Report
In this manuscript the chemical modification of rotenoneunder high-temperature and high-pressure
conditions using chromatographic separation has been presented.
I am sending a list of necessary corrections in
the manuscript that should be made before publication.
Sincerely,
Comments for author File: 
Comments.docx
Author Response
Reviewer 1
In this manuscript the chemical modification of rotenone under high-temperature and high-pressure conditions using chromatographic separation has been presented. I am sending a list of necessary corrections in the manuscript that should be made before publication.
Point 1: Line 89. To correct bracket
Response 1: We corrected bracket
Point 2: Figure 2. The labels on the X and Y axes should be clearer
Response 2: We changed high quality figure.
Point 3: Line 172 : You should check the order of the figures. The label for image four should be corrected. There are references to Figure 4 several times. Lines: 171, 185, 188,192, 196…
Response 3: We checked figure numbers and corrected Figure 4.
Point 4: Line 340: Check the Celsius markings
Response 4: We corrected Celsius markings and showed as red-color.
The authors wish to thank the reviewers for the constructive and helpful comments on the revision of this article.
Author Response File: Author Response.docx
Reviewer 2 Report
In the article, the authors presented investigate the chemical modification of rotenone under high-temperature and high-pressure conditions using chromatographic separation. These studies were conducted to demonstrate that thermolysis could be a viable method for producing new anti-inflammatory compounds from natural sources.
I believe that the studies presented in this work are useful. I do not have any remarks. The article is written in an appropriate way. Therefore, I suggest to accept the paper for publication in International Journal of Molecular Sciences
There are only two typos that need to be corrected:
- page 4, line 157 – “prodution” – it should be "production",
- page 3, line 69 – “compunds” – it should be "compounds".
Author Response
Reviewer 2
In the article, the authors presented investigate the chemical modification of rotenone under high-temperature and high-pressure conditions using chromatographic separation. These studies were conducted to demonstrate that thermolysis could be a viable method for producing new anti-inflammatory compounds from natural sources.
I believe that the studies presented in this work are useful. I do not have any remarks. The article is written in an appropriate way. Therefore, I suggest to accept the paper for publication in International Journal of Molecular Sciences
There are only two typos that need to be corrected:
Point 1: page 4, line 157 – “prodution” – it should be "production"
Response 1: We corrected word and showed as red-color.
Point 2: page 3, line 69 – “compunds” – it should be "compounds".
Response 2: We corrected word and showed as red-color.
The authors wish to thank the reviewers for the constructive and helpful comments on the revision of this article.
Author Response File: Author Response.docx
