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Review

Primary Cutaneous B-Cell Lymphomas with Large Cell Morphology: A Practical Review

by
Andrea Ronchi
1,
Paola Vitiello
2,
Giuseppe D’Abbronzo
1,
Stefano Caccavale
2,
Giuseppe Argenziano
2,
Antonello Sica
3,
Roberto Alfano
4,
Giovanni Savarese
5,
Massimiliano Berretta
6,
Immacolata Cozzolino
1 and
Renato Franco
1,*
1
Pathology Unit, Department of Mental Health and Physic and Preventive Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy
2
Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, 80131 Naples, Italy
3
Oncology Unit, Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80131 Naples, Italy
4
Department of Anesthesiology, Surgery and Emergency, University of Campania Luigi Vanvitelli, 80138 Naples, Italy
5
AMES, Centro Polidiagnostico Strumentale srl, 80013 Naples, Italy
6
Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(7), 6204; https://doi.org/10.3390/ijms24076204
Submission received: 28 February 2023 / Revised: 19 March 2023 / Accepted: 23 March 2023 / Published: 25 March 2023
(This article belongs to the Special Issue Latest Review Papers in Molecular Immunology 2023)
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Abstract

Most primary cutaneous lymphomas consist of T-cell lymphomas or small cell lymphomas; however, the skin may also be affected by lymphomas with large cell morphology, as a primary or secondary localization. A minority of cases consist of primary cutaneous B-cell lymphomas (PCBCLs). PCBCLs are a heterogeneous group of rare neoplasms with an overlapping morphological and immunohistochemical picture of the different subtypes. Nevertheless, differential diagnosis in the setting of this group of neoplasms is mandatory to identify the correct therapy and prognosis, but it may be challenging since, due to the rarity of these neoplasms, they may not always be familiar to pathologists. Indeed, immunohistochemistry may not be enough to distinguish the different histotypes, which overlap in immunohistochemical features. Furthermore, the ever-increasing knowledge of the molecular features of systemic B-cell lymphomas, such as gene rearrangements with clinical significance, has led in recent years to further investigation into the molecular landscape of PCBCLs with large cell morphology. This work aimed to provide a practical diagnostic guide for pathologists dealing with primary cutaneous large B-cell lymphomas.
Keywords: primary cutaneous lymphoma; follicle center lymphoma; diffuse large B-cell lymphoma; leg type primary cutaneous lymphoma; follicle center lymphoma; diffuse large B-cell lymphoma; leg type

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MDPI and ACS Style

Ronchi, A.; Vitiello, P.; D’Abbronzo, G.; Caccavale, S.; Argenziano, G.; Sica, A.; Alfano, R.; Savarese, G.; Berretta, M.; Cozzolino, I.; et al. Primary Cutaneous B-Cell Lymphomas with Large Cell Morphology: A Practical Review. Int. J. Mol. Sci. 2023, 24, 6204. https://doi.org/10.3390/ijms24076204

AMA Style

Ronchi A, Vitiello P, D’Abbronzo G, Caccavale S, Argenziano G, Sica A, Alfano R, Savarese G, Berretta M, Cozzolino I, et al. Primary Cutaneous B-Cell Lymphomas with Large Cell Morphology: A Practical Review. International Journal of Molecular Sciences. 2023; 24(7):6204. https://doi.org/10.3390/ijms24076204

Chicago/Turabian Style

Ronchi, Andrea, Paola Vitiello, Giuseppe D’Abbronzo, Stefano Caccavale, Giuseppe Argenziano, Antonello Sica, Roberto Alfano, Giovanni Savarese, Massimiliano Berretta, Immacolata Cozzolino, and et al. 2023. "Primary Cutaneous B-Cell Lymphomas with Large Cell Morphology: A Practical Review" International Journal of Molecular Sciences 24, no. 7: 6204. https://doi.org/10.3390/ijms24076204

APA Style

Ronchi, A., Vitiello, P., D’Abbronzo, G., Caccavale, S., Argenziano, G., Sica, A., Alfano, R., Savarese, G., Berretta, M., Cozzolino, I., & Franco, R. (2023). Primary Cutaneous B-Cell Lymphomas with Large Cell Morphology: A Practical Review. International Journal of Molecular Sciences, 24(7), 6204. https://doi.org/10.3390/ijms24076204

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