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Review

Diet as a Source of Acrolein: Molecular Basis of Aldehyde Biological Activity in Diabetes and Digestive System Diseases

by
Pawel Hikisz
1,* and
Damian Jacenik
2
1
Department of Oncobiology and Epigenetics, Faculty of Biology and Environmental Protection, University of Lodz, ul. Pomorska 141/143, 90-236 Lodz, Poland
2
Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, ul. Pomorska 141/143, 90-236 Lodz, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(7), 6579; https://doi.org/10.3390/ijms24076579
Submission received: 12 March 2023 / Revised: 25 March 2023 / Accepted: 31 March 2023 / Published: 31 March 2023
(This article belongs to the Section Molecular Biology)
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Abstract

Acrolein, a highly reactive α,β-unsaturated aldehyde, is a compound involved in the pathogenesis of many diseases, including neurodegenerative diseases, cardiovascular and respiratory diseases, diabetes mellitus, and the development of cancers of various origins. In addition to environmental pollution (e.g., from car exhaust fumes) and tobacco smoke, a serious source of acrolein is our daily diet and improper thermal processing of animal and vegetable fats, carbohydrates, and amino acids. Dietary intake is one of the main routes of human exposure to acrolein, which is a major public health concern. This review focuses on the molecular mechanisms of acrolein activity in the context of its involvement in the pathogenesis of diseases related to the digestive system, including diabetes, alcoholic liver disease, and intestinal cancer.
Keywords: acrolein; diabetes; diet; diabetic retinopathy; diabetic nephropathy; alcoholic liver disease; colorectal cancer; oxidative stress; DNA adducts; α,β-unsaturated aldehydes acrolein; diabetes; diet; diabetic retinopathy; diabetic nephropathy; alcoholic liver disease; colorectal cancer; oxidative stress; DNA adducts; α,β-unsaturated aldehydes
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MDPI and ACS Style

Hikisz, P.; Jacenik, D. Diet as a Source of Acrolein: Molecular Basis of Aldehyde Biological Activity in Diabetes and Digestive System Diseases. Int. J. Mol. Sci. 2023, 24, 6579. https://doi.org/10.3390/ijms24076579

AMA Style

Hikisz P, Jacenik D. Diet as a Source of Acrolein: Molecular Basis of Aldehyde Biological Activity in Diabetes and Digestive System Diseases. International Journal of Molecular Sciences. 2023; 24(7):6579. https://doi.org/10.3390/ijms24076579

Chicago/Turabian Style

Hikisz, Pawel, and Damian Jacenik. 2023. "Diet as a Source of Acrolein: Molecular Basis of Aldehyde Biological Activity in Diabetes and Digestive System Diseases" International Journal of Molecular Sciences 24, no. 7: 6579. https://doi.org/10.3390/ijms24076579

APA Style

Hikisz, P., & Jacenik, D. (2023). Diet as a Source of Acrolein: Molecular Basis of Aldehyde Biological Activity in Diabetes and Digestive System Diseases. International Journal of Molecular Sciences, 24(7), 6579. https://doi.org/10.3390/ijms24076579

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