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Review

Exercise-Induced Fibroblast Growth Factor-21: A Systematic Review and Meta-Analysis

by
Hyunjoong Kim
1,2,
Jihye Jung
3,
Sungeon Park
4,
Younglan Joo
4,
Sangbong Lee
4,
Jeongu Sim
4,
Jinhyeong Choi
4,
Hyun Lee
4,
Gyujeong Hwang
4 and
Seungwon Lee
5,*
1
Seogwangju Chung Yeon Rehabilitation Hospital, 61, Gaegeum-gil, Gwangju 72070, Republic of Korea
2
Department of Physical Therapy, Gwangju Health University, 73, Bungmun-daero 419, Gwangju 62287, Republic of Korea
3
Institute of SMART Rehabilitation, Sahmyook University, 815, Hwarang-ro, Seoul 01795, Republic of Korea
4
Department of Physical Therapy, Graduate School, Sahmyook University, 815, Hwarang-ro, Seoul 01795, Republic of Korea
5
Department of Physical Therapy, Sahmyook University, 815, Hwarang-ro, Seoul 01795, Republic of Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(8), 7284; https://doi.org/10.3390/ijms24087284
Submission received: 22 March 2023 / Revised: 13 April 2023 / Accepted: 13 April 2023 / Published: 14 April 2023
(This article belongs to the Special Issue Mechanisms and Interventions for Neurological and Psychological Disorders)
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Abstract

This systematic review aimed to synthesize and quantify the results of the studies investigating the changes in fibroblast growth factor-21 (FGF-21) induced by exercise. We searched for studies that did not differentiate between patients and healthy adults but compared them before and after exercise and with and without exercise. For quality assessment, the risk-of-bias assessment tool for nonrandomized studies and the Cochrane risk-of-bias tool were used. A quantitative analysis was performed using the standardized mean difference (SMD) and random-effects model in RevMan 5.4. A total of 94 studies were searched in international electronic databases, and after screening, 10 studies with 376 participants were analyzed. Compared with no exercise, there was a significant increase in the FGF-21 levels from before to after exercise (SMD = 1.05, 95% confidence interval (CI), 0.21 to 1.89). The changes in FGF-21 levels in the exercise group showed a significant difference from the levels in the controls. The results of the random-effects model were as follows: SMD = 1.12; 95% CI, −0.13 to 2.37. While the data on acute exercise were not synthesized in this study, FGF-21 levels generally increased after chronic exercise compared with no exercise.
Keywords: fibroblast growth factor-21; exercise; endocrine cells; physical activity fibroblast growth factor-21; exercise; endocrine cells; physical activity

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MDPI and ACS Style

Kim, H.; Jung, J.; Park, S.; Joo, Y.; Lee, S.; Sim, J.; Choi, J.; Lee, H.; Hwang, G.; Lee, S. Exercise-Induced Fibroblast Growth Factor-21: A Systematic Review and Meta-Analysis. Int. J. Mol. Sci. 2023, 24, 7284. https://doi.org/10.3390/ijms24087284

AMA Style

Kim H, Jung J, Park S, Joo Y, Lee S, Sim J, Choi J, Lee H, Hwang G, Lee S. Exercise-Induced Fibroblast Growth Factor-21: A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences. 2023; 24(8):7284. https://doi.org/10.3390/ijms24087284

Chicago/Turabian Style

Kim, Hyunjoong, Jihye Jung, Sungeon Park, Younglan Joo, Sangbong Lee, Jeongu Sim, Jinhyeong Choi, Hyun Lee, Gyujeong Hwang, and Seungwon Lee. 2023. "Exercise-Induced Fibroblast Growth Factor-21: A Systematic Review and Meta-Analysis" International Journal of Molecular Sciences 24, no. 8: 7284. https://doi.org/10.3390/ijms24087284

APA Style

Kim, H., Jung, J., Park, S., Joo, Y., Lee, S., Sim, J., Choi, J., Lee, H., Hwang, G., & Lee, S. (2023). Exercise-Induced Fibroblast Growth Factor-21: A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences, 24(8), 7284. https://doi.org/10.3390/ijms24087284

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