Transient Receptor Potential (TRP) Channels in Pain, Neuropsychiatric Disorders, and Epilepsy

Yang, Felix; Sivils, Andy; Cegielski, Victoria; Singh, Som; Chu, Xiang-Ping

doi:10.3390/ijms24054714

Open AccessReview

Transient Receptor Potential (TRP) Channels in Pain, Neuropsychiatric Disorders, and Epilepsy

by

Felix Yang

^†,

Andy Sivils

^†,

Victoria Cegielski

,

Som Singh

and

Xiang-Ping Chu

^*

Department of Biomedical Sciences, School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USA

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Int. J. Mol. Sci. 2023, 24(5), 4714; https://doi.org/10.3390/ijms24054714

Submission received: 16 January 2023 / Revised: 21 February 2023 / Accepted: 22 February 2023 / Published: 1 March 2023

(This article belongs to the Special Issue Mechanisms and Interventions for Neurological and Psychological Disorders)

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Abstract

Pharmacomodulation of membrane channels is an essential topic in the study of physiological conditions and disease status. Transient receptor potential (TRP) channels are one such family of nonselective cation channels that have an important influence. In mammals, TRP channels consist of seven subfamilies with a total of twenty-eight members. Evidence shows that TRP channels mediate cation transduction in neuronal signaling, but the full implication and potential therapeutic applications of this are not entirely clear. In this review, we aim to highlight several TRP channels which have been shown to mediate pain sensation, neuropsychiatric disorders, and epilepsy. Recent findings suggest that TRPM (melastatin), TRPV (vanilloid), and TRPC (canonical) are of particular relevance to these phenomena. The research reviewed in this paper validates these TRP channels as potential targets of future clinical treatment and offers patients hope for more effective care.

Keywords: transient receptor potential channels; TRP; TRPM; TRPV; TRPC; pain; depression; bipolar; epilepsy; seizure

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MDPI and ACS Style

Yang, F.; Sivils, A.; Cegielski, V.; Singh, S.; Chu, X.-P. Transient Receptor Potential (TRP) Channels in Pain, Neuropsychiatric Disorders, and Epilepsy. Int. J. Mol. Sci. 2023, 24, 4714. https://doi.org/10.3390/ijms24054714

AMA Style

Yang F, Sivils A, Cegielski V, Singh S, Chu X-P. Transient Receptor Potential (TRP) Channels in Pain, Neuropsychiatric Disorders, and Epilepsy. International Journal of Molecular Sciences. 2023; 24(5):4714. https://doi.org/10.3390/ijms24054714

Chicago/Turabian Style

Yang, Felix, Andy Sivils, Victoria Cegielski, Som Singh, and Xiang-Ping Chu. 2023. "Transient Receptor Potential (TRP) Channels in Pain, Neuropsychiatric Disorders, and Epilepsy" International Journal of Molecular Sciences 24, no. 5: 4714. https://doi.org/10.3390/ijms24054714

APA Style

Yang, F., Sivils, A., Cegielski, V., Singh, S., & Chu, X.-P. (2023). Transient Receptor Potential (TRP) Channels in Pain, Neuropsychiatric Disorders, and Epilepsy. International Journal of Molecular Sciences, 24(5), 4714. https://doi.org/10.3390/ijms24054714

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Transient Receptor Potential (TRP) Channels in Pain, Neuropsychiatric Disorders, and Epilepsy

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