Hyaluronic Acid-Based Nanosystems for CD44 Mediated Anti-Inflammatory and Antinociceptive Activity
Abstract
:1. Introduction
2. HA and Inflammation: Influence of Molecular Weight
3. HA-Based Nanosystems
3.1. Drug Delivery Systems
3.2. Macrophage Targeting Nanosystems
3.3. Self-Assembling Nanosystems
4. Hyaluronic Acid Nanosystems, Study Gaps and Future Directions
5. Conclusions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Nanosystem | HA in Nanosystem | Administration Route | Formulation Method | Characterisation | Drug | Therapy | Reference |
---|---|---|---|---|---|---|---|
Drug Delivery Systems | |||||||
HA-nanogel loading quercetin | 200 kDa Sodium hyaluronate | - | Solvent–non solvent method | Size: 211.3 nm ζ: −35.8 ± 1.3 mV | quercetin | Anti-inflammatory effect in breast cancer tumour cells | [68] |
HA-nanogel loading quercetin | 200 kDa Sodium hyaluronate | - | Solvent–non solvent method | Size: 197.3 ± 3.3 nm ζ: −31.3 ± 1.1 mV | quercetin | Anti-inflammatory effect in glioblastoma tumour cells | [69] |
Non-crosslinked HA-fibrin hydrogels containing HA-shell nanocapsules co-loaded with dexamethasone and galectin-3 inhibitor | 40 kDa, 700 kDa, 1.5 MDa Sodium hyaluronate | Intra-articular | Solvent displacement method | Size: 122–135 nm ζ: −29 ± 5 mV | dexamethasone and galectin-3 inhibitor | Therapy for inflammatory joint diseases | [70] |
HA nanocrystal hydrogels loading baicalin | 800–1000 kDa Sodium hyaluronate | TDD system | Homogenization | Size: 189.21 ± 0.36 nm | baicalin | anti-inflammation | [79] |
Thioether-grafted HA nanofibrous hydrogel | 1400 kDa Sodium hyaluronate, thioether modified and crosslinked with Fe3+ | TDD system | Electrospinning | Size: 60 ± 11 nm | HMW HA | wound healing in diabetic conditions | [82] |
HA-based mangiferin nanoemulsion | 40-50 kDa and 1–1.2 MDa HA | TDD system | Emulsion method | Size: 296 nm ζ: −30 mV | mangiferin | Anti-inflammation for skin lesions | [83] |
Curcumin-loaded HA-nanovesicles | 200–400 kDa Sodium Hyaluronate | TDD system | Organic solvent-free dispersion method | Size: 157–166 nm ζ: 24 ± 4 mV | curcumin | Anti-inflammation for skin lesions | [84] |
HA nanostructured lipid carriers loading ropivacaine and dexmedetomidine | 3 kDa HA, PEG-DSPE modified | TDD system | Solvent diffusion method | Size: 108.2 ± 3.3 nm ζ: −30.7 ± 2.8 mV | Ropivacaine and dexmedetomidine | Local analgesic | [85] |
HA-modified nanostructured lipid carriers loading bupivacaine | 300 kDa HA | Local administration | Emulsification and solvent injection methods | Size: 154.6 ± 5.1 nm ζ: −40.1 ± 3.9 mV | bupivacaine | Local anaesthetic | [87] |
HA-chondroitin sulfate medical device (Esoxx) | - | Oral delivery | - | - | Esoxx® | Gastritis | [88] |
Macrophage-Targeting Nanosystems | |||||||
HA-polylactide nanoparticles encapsulating curcumin | 20 kDa Sodium hyaluronate | - | Solvent evaporation method | Size: 102.5 nm ζ: −24.5 ± 2.2 mV | Curcumin | Macrophage repolarisation | [43] |
HA-chitosan lipid nanostructures loading lidocaine (layer-by-layer) | - | TDD system | Melt-emulsification method | Size: 181.2 nm ζ: +37.6 ± 4.2 mV | Lidocaine | Local anaesthesia | [89] |
HA-nanoparticles loading pDNA | 20 kDa Sodium hyaluronate | in vitro transfection | Coupling reaction | Size: 185.9 nm ζ: −11.6 mV | pDNA | Macrophage repolarisation | [91] |
HA-nanoparticles encapsulating siTNFα | 20 kDa Sodium hyaluronate | Transfection | - | Size: 85–110 nm | TNF-α specific small interfering RNA | Inhibiting LPS-induced inflammation | [93] |
HA containing ethosomes encapsulating rhodamine | 150 kDa Sodium hyaluronate | TDD system | Homogenization | Size: 593.8 nm ζ: +10 mV | Rhodamine | Quick, high-efficiency TDD system | [94] |
pH-responsive HA-loaded PLGA nanoparticles | 750–1000 kDa Sodium hyaluronate | Intra-articular injection | Single-emulsion solvent evaporation method | Size: 202.7 ± 2.3 nm ζ: −21.0 mV | HMW HA | Osteoarthritis | [100] |
HA decorated on PLGA nanoparticle surface | 21–40 kDa Sodium hyaluronate | Intra-articular injection | Double-emulsion solvent method | Size: 200 ± 2 nm ζ: −23 ± 2 mV | HMW HA | Osteoarthritis | [101] |
Self-Assembling Nanosystems | |||||||
HA-nanoparticles loading BDS | 10–25 kDa Sodium hyaluronate, DA modified for amphiphilicity | in vitro dynamic dialysis drug release study | Thin-film hydration method | Size: 207 ± 11 nm ζ: −14.56 ± 0.22 mV | Budesonide | IBD-induced pain/inflammation | [109] |
HA-PLGA hybrid systems | 1.5–1.8 MDa Sodium hyaluronate | Viscosupplementation | Spontaneous emulsification solvent diffusion method | Size: 373 ± 270 nm ζ: −16.65 mV | HMW HA | Osteoarthritis | [110] |
Amphiphilic HA-nanoparticles | 10 kDa HA | Intra-articular injection | Chemical conjugation | Size: 221 ± 1 nm ζ: 15.08 ± 0.83 mV | LMW HA | OA treatment | [111] |
Gel-core HA nanovesicles | 8–11.7 kDa HA | TDD system | Thin layer evaporation technique | Size: 232.8 ± 7.2 nm ζ: −45.1 ± 8.3 mV | HMW HA | OA therapy | [112] |
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Salathia, S.; Gigliobianco, M.R.; Casadidio, C.; Di Martino, P.; Censi, R. Hyaluronic Acid-Based Nanosystems for CD44 Mediated Anti-Inflammatory and Antinociceptive Activity. Int. J. Mol. Sci. 2023, 24, 7286. https://doi.org/10.3390/ijms24087286
Salathia S, Gigliobianco MR, Casadidio C, Di Martino P, Censi R. Hyaluronic Acid-Based Nanosystems for CD44 Mediated Anti-Inflammatory and Antinociceptive Activity. International Journal of Molecular Sciences. 2023; 24(8):7286. https://doi.org/10.3390/ijms24087286
Chicago/Turabian StyleSalathia, Saniya, Maria Rosa Gigliobianco, Cristina Casadidio, Piera Di Martino, and Roberta Censi. 2023. "Hyaluronic Acid-Based Nanosystems for CD44 Mediated Anti-Inflammatory and Antinociceptive Activity" International Journal of Molecular Sciences 24, no. 8: 7286. https://doi.org/10.3390/ijms24087286