ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis?
Abstract
:1. Introduction
1.1. Pathogenesis and the Role of Cellular Cross-Talk
1.2. ADAMs
2. Role of ADAM10/17 in CKD
2.1. ADAM17 and Its Role in CKD
2.2. ADAM10 and Its Role in CKD
3. Role of ADAM10/17 in Atherosclerosis
3.1. Substrate Cleavage by ADAM10/17 in the Context of Inflammation
3.2. ADAM17 as a Mediator of Atherosclerosis
3.3. ADAM10 as a Mediator of Atherosclerosis
4. ADAMs in Cardiorenal Cross-Talk
5. Future Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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General Risk Factors for CKD | General Risk Factors for Atherosclerosis | Risk Factors for CKD-Induced Atherosclerosis |
---|---|---|
Age | Age | Age |
Diabetes mellitus | Diabetes mellitus | Diabetes mellitus |
Hypertension | Hypertension | Augmented hypertension |
Dyslipidemia | Abnormal lipid and protein modifications | |
Male gender | Uremic toxins | |
Physical inactivity | Altered mineral bone metabolism | |
Smoking | Oxidative stress | |
Stress | ||
Systemic low-grade inflammation |
ADAM | Inflammatory Mediators | Cell Process in Kidney Function/Disease | Reference |
---|---|---|---|
ADAM10 | Betacellulin | Differentiation, fibrosis, migration, permeability, proliferation | [64,65,66] |
CADM1 | Adhesion, apoptosis | [67,68,69] | |
Corin | Blood pressure | [70] | |
E-cadherin | Cell adhesion, wnt-signaling | [71,72] | |
VE-cadherin | Endothelial permeability, angiogenesis | [73,74] | |
ADAM17 | ACE2 | Endothelial dysfunction, inflammation, oxidative stress | [75,76,77,78,79,80] |
AREG | Inflammation, fibrosis | [61,64] | |
CD163 | Inflammation, macrophage activation | [81] | |
CD40 | Immune suppression | [82] | |
cKit ligand | Angiogenesis | [83] | |
EMMPRIN | Lymphocyte cycling | [84] | |
EPCR | Anticoagulation | [85] | |
Ephrin B4 | Sprouting | [84] | |
FLT3L | Lymphopoiesis, progenitor differentiation | [86] | |
IL-1R2 | Anti-inflammatory | [87] | |
IGFR1 | Cell survival | [84] | |
Jagged 1 | Cell differentiation | [88] | |
L-selectin | Adhesion | [89] | |
L1-CAM | Adhesion | [90] | |
Nox4 | Oxidative stress | [91] | |
NRP-1 | Angiogenesis | [92] | |
PECAM-1 | Adhesion | [84] | |
Sema 4D | Platelet activation | [93] | |
Tie2 | Angiogenesis | [94] | |
TGFα | Cell proliferation | [64,95] | |
TNFR1 | Inflammation | [87,96,97] | |
TNRF2 | Inflammation | [96,97] | |
VCAM-1 | Adhesion, inflammation | [98] | |
ADAM10, | CD44 | Angiogenesis, inflammation, migration | [99,100] |
ADAM17 | CD74 | Leukocyte migration | [101] |
CX3CL1 | Adhesion, inflammation, transmigration | [102,103,104,105,106] | |
CXCL16 | Leukocyte adhesion, inflammation | [104,105,106,107,108,109,110] | |
DLL1 | Migration, proliferation | [111] | |
HB-EGF | Angiogenesis, cell survival, fibrosis, proliferation | [84,95,112,113] | |
IL-6R | Inflammation | [114,115,116] | |
ICAM-1 | Leukocyte recruitment, inflammation | [117,118] | |
JAM-A | Angiogenesis, transmigration | [119] | |
KIM-1 | Efferocytosis | [120] | |
Klotho | Calcification, fibrosis, vascular dysfunction | [121,122,123,124,125,126,127,128] | |
M-CSFR | Inflammation | [129] | |
Meprin | Apoptosis, fibrosis, necrosis | [130,131,132] | |
Notch | Angiogenesis, differentiation, EMT, fibrosis, inflammation | [133,134,135,136,137,138,139] | |
Syndecan-1 | Adhesion, migration, proliferation | [140,141,142,143,144] | |
Syndecan-4 | Adhesion, migration, proliferation | [143,145] | |
TNFα | Fibrosis, inflammation | [61,97,146,147,148] | |
TRANCE (RANKL) | Calcification, survival/proliferation, osteogenic SMC differentiation | [149,150,151] | |
VEGFR2 | Angiogenesis, cell survival, homeostasis, proliferation | [74,92] |
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Maas, S.L.; Donners, M.M.P.C.; van der Vorst, E.P.C. ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis? Int. J. Mol. Sci. 2023, 24, 7309. https://doi.org/10.3390/ijms24087309
Maas SL, Donners MMPC, van der Vorst EPC. ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis? International Journal of Molecular Sciences. 2023; 24(8):7309. https://doi.org/10.3390/ijms24087309
Chicago/Turabian StyleMaas, Sanne L., Marjo M. P. C. Donners, and Emiel P. C. van der Vorst. 2023. "ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis?" International Journal of Molecular Sciences 24, no. 8: 7309. https://doi.org/10.3390/ijms24087309